Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland.
Department of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland.
Int J Mol Sci. 2021 Feb 25;22(5):2295. doi: 10.3390/ijms22052295.
Endometriosis is a gynecological disease, the pathogenesis of which seems to be directly associated with inflammatory processes. Serum concentrations of IL-1β, IL-6, hs-CRP, IgG, YKL 40 and PRL, in comparison to the well-known CA 125 levels, were studied with the aim of identifying an additional noninvasive inflammatory marker or set of markers characteristic for endometriosis. The study group included 43 women with endometriosis (E), 35 women with benign gynecological disorders but without endometriosis (NE, non-endometriosis) as a comparative group, and a control group consisting of 18 healthy subjects (C). The serum concentrations of IL-1β, IL-6, hs-CRP, YKL-40, PRL and CA 125 were significantly higher in the E group (median values: 0.41 pg/mL, 2.42 pg/mL, 2.33 mg/L, 79.30 ng/mL, 21.88 ng/mL and 68.00 U/mL, respectively) than in the control group (median values: 0.21 pg/mL, 0.98 pg/mL, 0.52 mg/L, 49.77 ng/mL, 12.08 ng/mL and 12.20 U/mL respectively), with the significance of = 0.011, < 0.001, = 0.028, = 0.005, < 0.001 and < 0.001, respectively. The IgG concentrations were significantly lower in the endometriosis group (median value: 1061.21 mg/dL) as compared to healthy women (median value: 1210.50 mg/dL; = 0.025). Significant differences in concentrations of IL-6 ( = 0.040), hs-CRP ( = 0.007) and CA 125 ( < 0.001) were observed in stage III vs. stage IV of endometriosis. Significantly higher concentrations of IL-6 ( = 0.010), hs-CRP ( = 0.037) and PRL ( < 0.001) were observed in the NE group vs. the control group. Only CA 125 concentrations were significantly higher in endometriosis patients as compared to the non-endometriosis group ( < 0.001). The proposed panel of inflammatory markers, especially IL-6, PRL and CA 125, may become a useful tool to identify women with advanced endometriosis who could qualify for treatment.
子宫内膜异位症是一种妇科疾病，其发病机制似乎与炎症过程直接相关。本研究旨在寻找一种额外的非侵入性炎症标志物或一组与子宫内膜异位症相关的标志物，因此检测了白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、超敏 C 反应蛋白（hs-CRP）、免疫球蛋白 G（IgG）、YKL-40 和催乳素（PRL）在血清中的浓度。研究对象包括 43 名子宫内膜异位症患者（E 组）、35 名患有良性妇科疾病但无子宫内膜异位症的患者（非子宫内膜异位症组，NE）和 18 名健康对照者（C 组）。E 组患者血清中 IL-1β（中位数：0.41 pg/mL）、IL-6（中位数：2.42 pg/mL）、hs-CRP（中位数：2.33 mg/L）、YKL-40（中位数：79.30 ng/mL）、PRL（中位数：21.88 ng/mL）和 CA125（中位数：68.00 U/mL）的浓度明显高于 C 组（中位数：0.21 pg/mL、0.98 pg/mL、0.52 mg/L、49.77 ng/mL、12.08 ng/mL 和 12.20 U/mL），差异有统计学意义（ = 0.011、< 0.001、 = 0.028、 = 0.005、< 0.001 和 < 0.001）。E 组患者 IgG 浓度（中位数：1061.21 mg/dL）明显低于 C 组（中位数：1210.50 mg/dL； = 0.025）。子宫内膜异位症 3 期和 4 期患者的 IL-6（ = 0.040）、hs-CRP（ = 0.007）和 CA125（< 0.001）浓度差异有统计学意义。与 C 组相比，NE 组患者的 IL-6（ = 0.010）、hs-CRP（ = 0.037）和 PRL（< 0.001）浓度明显升高。与非子宫内膜异位症组相比，子宫内膜异位症患者的 CA125 浓度明显升高（< 0.001）。该炎症标志物联合检测，尤其是 IL-6、PRL 和 CA125，可能成为识别有治疗需求的晚期子宫内膜异位症患者的有用工具。
