Department of Ophthalmology, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, 08308, Seoul, Korea.
BMC Ophthalmol. 2021 Jan 12;21(1):32. doi: 10.1186/s12886-021-01804-x.
In this study, we aimed to compare the choroidal thickness between a group of Korean patients with inactive thyroid eye disease (TED) and a control group of Korean patients and to analyze the variables affecting choroidal thickness.
Patients diagnosed with inactive TED and without TED who underwent optical coherence tomography and axial length measurements were included and classified into the TED group and control group. Choroidal thickness was measured using images acquired in enhanced depth imaging (EDI) mode by cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, UAS) at the central fovea and points 1.5 mm nasal and 1.5 mm temporal from the central fovea using a caliper tool provided by OCT software.
The mean central foveal choroidal thickness was 294.2 ± 71.4 µm and 261.1 ± 47.4 µm in the TED and control groups, respectively, while the mean temporal choroidal thickness was 267.6 ± 67.5 µm and 235.7 ± 41.3 µm in the TED and control groups, respectively, showing significant differences between the two groups (P = 0.011, P = 0.008). The mean nasal choroidal thickness was 232.1 ± 71.7 µm and 221.1 ± 59.9 µm in the TED and control groups, respectively, showing no significant difference between the two groups (P = 0.421). Multivariate regression analysis showed the factors affecting central foveal choroidal thickness were age, axial length, and degree of exophthalmos, and factors affecting temporal choroidal thickness were age and degree of exophthalmos.
Central foveal and temporal choroidal thickness were significantly thicker in patients with inactive TED than in control subjects, while age, axial length, and degree of exophthalmos were identified as major factors affecting choroidal thickness.
本研究旨在比较一组韩国甲状腺眼病（TED）活动期患者与对照组韩国患者的脉络膜厚度，并分析影响脉络膜厚度的变量。
纳入接受光学相干断层扫描和眼轴长度测量的诊断为非活动期 TED 患者和无 TED 患者，并将其分为 TED 组和对照组。使用 Cirrus HD-OCT（德国卡尔蔡司公司，加利福尼亚州都柏林）的 EDI 模式获取中央凹和距中央凹 1.5mm 鼻侧及颞侧的图像，使用 OCT 软件提供的卡尺工具测量脉络膜厚度。
TED 组和对照组的中央凹脉络膜厚度平均值分别为 294.2±71.4μm 和 261.1±47.4μm，颞侧脉络膜厚度平均值分别为 267.6±67.5μm 和 235.7±41.3μm，两组间差异有统计学意义（P=0.011，P=0.008）。鼻侧脉络膜厚度平均值分别为 232.1±71.7μm 和 221.1±59.9μm，两组间差异无统计学意义（P=0.421）。多变量回归分析显示，影响中央凹脉络膜厚度的因素为年龄、眼轴长度和眼球突出度，影响颞侧脉络膜厚度的因素为年龄和眼球突出度。
非活动期 TED 患者的中央凹和颞侧脉络膜厚度明显较对照组增厚，而年龄、眼轴长度和眼球突出度是影响脉络膜厚度的主要因素。
