三种谱域光学相干断层扫描系统测量脉络膜厚度的可重复性。
Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems.
机构信息
New England Eye Center, Tufts Medical Center, Boston, Massachusetts 02111, USA.
出版信息
Ophthalmology. 2012 Jan;119(1):119-23. doi: 10.1016/j.ophtha.2011.07.002. Epub 2011 Sep 23.
PURPOSE
To investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography (SD-OCT) instruments: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), and Optovue RTVue (Optovue Inc., Fremont, CA).
DESIGN
Cross-sectional non-interventional study.
PARTICIPANTS
Images were obtained in 28 eyes of 28 healthy undilated volunteers without ocular pathology in a clinical setting.
METHODS
All subjects were imaged on the fovea using Cirrus HD 1-line raster, Spectralis enhanced depth imaging (EDI), and RTVue retina-cross.
MAIN OUTCOME MEASURES
The choroid was measured subfoveally, 750 μm temporal, and 750 μm nasal to the fovea. All measurements were performed by 2 independent observers. Two-way analysis of variance (ANOVA) with Bonferroni's post-test, Pearson correlation, and Bland-Altman analysis were used to compare measurements.
RESULTS
The group of 28 subjects consisted of 7 men and 21 women, with an average age of 35.2 years (range, 23-64 years). A 2-way ANOVA with Bonferroni's post-test revealed no significant difference in the average subfoveal choroidal thickness (P > 0.05) among systems for any location: subfoveally, 750 μm temporal, and 750 μm nasal to the fovea. The measurements of choroidal thickness from any pair of 3 instruments (Cirrus vs. Spectralis, Cirrus vs. RTVue, Spectralis vs. RTVue) were also strongly correlated. The Pearson correlation among all 2 system pairs of the 3 systems was greater than 0.9 (P < 0.0001). The 95% limits of agreement among 4 choroidal thickness measurements were +11.21% to -13.57% (bias -1.17) between Cirrus and RTVue, +10.85% to -12.45% (bias -0.80) between Spectralis and RTVue, and +12.81% to -13.33% (bias -0.25) between Cirrus and Spectralis.
CONCLUSIONS
In our population of young healthy adults with normal vision, there was good reproducibility among choroidal thickness measurements of images acquired with Cirrus, Spectralis, and RTVue.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
目的
研究在 3 种谱域光学相干断层扫描（SD-OCT）仪器（蔡司 Cirrus HD-OCT、海德堡 Spectralis 和 Optovue RTVue）上对正常受试者的脉络膜厚度测量的可重复性。
设计
横断面非干预性研究。
参与者
在临床环境中，在 28 名无眼部病变的健康未散瞳志愿者的 28 只眼中获得图像。
方法
使用 Cirrus HD 1 线光栅、Spectralis 增强深度成像（EDI）和 RTVue 视网膜交叉对所有受试者的黄斑进行成像。
主要观察指标
在黄斑下、750μm 颞侧和黄斑鼻侧进行脉络膜测量。所有测量均由 2 位独立观察者进行。采用双因素方差分析（ANOVA）和 Bonferroni 事后检验、Pearson 相关分析和 Bland-Altman 分析比较测量值。
结果
28 名受试者中包括 7 名男性和 21 名女性，平均年龄 35.2 岁（范围，23-64 岁）。双因素方差分析和 Bonferroni 事后检验显示，在任何位置（黄斑下、750μm 颞侧和黄斑鼻侧），系统之间的平均黄斑下脉络膜厚度均无显著差异（P>0.05）。任何 3 种仪器（Cirrus 与 Spectralis、Cirrus 与 RTVue、Spectralis 与 RTVue）的脉络膜厚度测量结果也具有很强的相关性。3 种系统中所有 2 个系统对的 Pearson 相关系数均大于 0.9（P<0.0001）。Cirrus 和 RTVue 之间的 4 次脉络膜厚度测量的 95%一致性界限为+11.21%至-13.57%（偏倚-1.17），Spectralis 和 RTVue 之间为+10.85%至-12.45%（偏倚-0.80），Cirrus 和 Spectralis 之间为+12.81%至-13.33%（偏倚-0.25）。
结论
在我们的视力正常的年轻健康成年人人群中，Cirrus、Spectralis 和 RTVue 采集的图像的脉络膜厚度测量具有良好的可重复性。
利益冲突
参考文献后可能会发现专有或商业披露。
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