Ma Xiaoqing, Li Yan, Wen Ji, Zhao Yu
Department of Obstetrics and Gynecology, Fengrun District People's Hospital No. 456 Caoxueqin West Road, Fengrun District, Tangshan 064000, Hebei Province, China.
Reproductive Medical Center, The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine Ji'nan 250001, Shandong Province, China.
Am J Transl Res. 2020 Dec 15;12(12):8137-8146. eCollection 2020.
N6-methyladenosine (m6A) RNA methylation, which is related to the occurrence and development of cancer, is dynamically modulated by m6A RNA methylation regulators ("writers", "erasers" and "readers"). In this paper, we demonstrated that most of the 13 major m6A RNA methylation regulators were differently expressed in 306 cervical cancer tissues stratified according to different clinicopathological characteristics. We applied consensus clustering technique to analyze m6A RNA methylation regulators and identified two subgroups of cervical cancer, named RM1/2. Compared with the RM1, the RM2 had a poorer prognosis and lower overall survival (OS). This result suggested that m6A RNA methylation regulators were closely related to cervical cancer. Based on this result, we used m6A RNA methylation regulators to derive a risk marker that not only is an independent prognostic marker but also can predict the clinicopathological characteristics of cervical cancer. In conclusion, m6A RNA methylation regulator is a key player in the malignant progression of cervical cancer and has potential role in the stratification of prognosis and the formulation of treatment strategies.
N6-甲基腺苷（m6A）RNA甲基化与癌症的发生发展相关，受m6A RNA甲基化调节因子（“书写者”“擦除者”和“阅读者”）动态调控。在本文中，我们证明，在根据不同临床病理特征分层的306例宫颈癌组织中，13种主要的m6A RNA甲基化调节因子大多表达各异。我们应用一致性聚类技术分析m6A RNA甲基化调节因子，并鉴定出宫颈癌的两个亚组，命名为RM1/2。与RM1相比，RM2预后较差，总生存期（OS）较低。这一结果表明，m6A RNA甲基化调节因子与宫颈癌密切相关。基于这一结果，我们利用m6A RNA甲基化调节因子得出一个风险标志物，它不仅是一个独立的预后标志物，还能预测宫颈癌的临床病理特征。总之，m6A RNA甲基化调节因子是宫颈癌恶性进展的关键因素，在预后分层和治疗策略制定方面具有潜在作用。
