尼泊尔加德满都学童中诱导性克林霉素耐药性及相关基因研究
Inducible clindamycin resistance and genes in in school children in Kathmandu, Nepal.
作者信息
Timsina Roshan, Shrestha Upasana, Singh Anjana, Timalsina Bivek
机构信息
Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.
Center for Health & Disease Studies-Nepal (CHDS), Shankhamul, Kathmandu, Nepal.
出版信息
Future Sci OA. 2020 Oct 20;7(1):FSO361. doi: 10.2144/fsoa-2020-0092.
AIM
Resistance to methicillin and Macrolide-Lincosamide and Streptogramins B and their association with genes in are unknown in Nepal.
MATERIALS & METHODS: Nonduplicate nasal swabs from 160 school children were collected from April to September 2018 and processed using standard microbiological procedures.
RESULTS
Out of 160 samples, 64 (40%) were in which 17 (26.6%) were methicillin-resistance (MRSA). D-test identified 15 (23.4%) as inducible clindamycin-resistant, which were more prevalent in MRSA (76.4%) than methicillin-sensitive (MSSA; 4.2%). 18.7% of isolates harbored the gene followed by (15.6%) and (3.1%), and were more in MRSA than MSSA.
CONCLUSION
To prevent treatment failure by inducible resistance, D-test must be performed on erythromycin-resistant and/or clindamycin-sensitive isolates.
目的
在尼泊尔，耐甲氧西林、大环内酯-林可酰胺-链阳菌素B及其与基因的关联尚不清楚。
材料与方法
2018年4月至9月收集了160名学童的非重复鼻拭子，并采用标准微生物学程序进行处理。
结果
在160份样本中，64份（40%）为金黄色葡萄球菌，其中17份（26.6%）为耐甲氧西林金黄色葡萄球菌（MRSA）。D试验确定15份（23.4%）为诱导型克林霉素耐药，在MRSA中比甲氧西林敏感金黄色葡萄球菌（MSSA；4.2%）更普遍。18.7%的分离株携带erm基因，其次是mef（15.6%）和vga（3.1%），且在MRSA中比MSSA中更多见。
结论
为防止诱导耐药导致治疗失败，必须对红霉素耐药和/或克林霉素敏感的分离株进行D试验。
Zotero 插件