饮茶与中老年新加坡人慢性阻塞性肺疾病风险的关系。
Tea Consumption and Risk of Chronic Obstructive Pulmonary Disease in Middle-Aged and Older Singaporean Adults.
机构信息
Gerontology Research Programme, Department of Psychological Medicine, National University of Singapore, Singapore.
Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
出版信息
Int J Chron Obstruct Pulmon Dis. 2021 Jan 7;16:13-23. doi: 10.2147/COPD.S273406. eCollection 2021.
OBJECTIVE
The anti-oxidant and anti-inflammatory actions of phytochemicals and the smooth muscle relaxant actions of theophylline present in tea may confer pulmonary protection and reduce COPD risk. We investigated tea consumption (black, oolong, or green) association with COPD risks in a population-based cohort study of older adults aged ≥55.
METHODS
GOLD criteria was used to identify prevalent and incident cases of COPD (FEV/FVC <0.70) among 4617 participants and 920 participants free of COPD at baseline who were assessed at follow-up 4.5 years later.
RESULTS
Prevalent cases of COPD consumed less tea than their non-COPD counterparts. Estimated odds ratio (OR) and 95% confidence intervals (95% CI) of association with prevalent COPD, adjusted for age, sex, ethnicity, housing type, smoking, alcohol, physical activity and BMI declined across tea consumption levels (p-trend=0.048), and was lowest for ≥3 cups/day (OR=0.77, 95% CI=0.61-0.96). The cumulated incidence of COPD declined across tea consumption categories (p-trend=0.012) and the lowest OR of association (OR=0.35, 95% CI=0.17-0.69) with consuming ≥3 cups/day after co-variate adjustment.
CONCLUSION
Different kinds of tea showed similar non-significant trends of associations but appeared to be strongest for green tea. Tea consumption in this Asian population was associated with lowered COPD prevalence and incidence.
目的
植物化学物质的抗氧化和抗炎作用以及茶碱的平滑肌松弛作用可能对肺部有保护作用，降低 COPD 的风险。我们在一项针对≥55 岁老年人的基于人群的队列研究中，调查了茶的消费（红茶、乌龙茶或绿茶）与 COPD 风险的关系。
方法
使用 GOLD 标准在 4617 名参与者中确定了 COPD（FEV/FVC<0.70）的现患病例和在基线时无 COPD 的 920 名参与者，这些参与者在 4.5 年后的随访中进行了评估。
结果
现患 COPD 患者的茶消费量低于非 COPD 患者。调整年龄、性别、种族、住房类型、吸烟、饮酒、身体活动和 BMI 后，与现患 COPD 的关联的估计比值比（OR）和 95%置信区间（95%CI）随着茶消费量的增加而降低（趋势检验 p=0.048），每天≥3 杯时最低（OR=0.77，95%CI=0.61-0.96）。随着茶消费类别的增加，COPD 的累积发病率下降（趋势检验 p=0.012），在调整协变量后，与每天≥3 杯的关联的最低 OR（OR=0.35，95%CI=0.17-0.69）。
结论
不同种类的茶显示出相似的非显著关联趋势，但似乎以绿茶最强。在这个亚洲人群中，茶的消费与 COPD 的患病率和发病率降低有关。
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