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饮茶与新加坡纵向老龄化研究中的抑郁随诊。

Tea Consumption and Depression from Follow Up in the Singapore Longitudinal Ageing Study.

机构信息

Tze Pin Ng (MD), Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Level 9, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Fax: 65-67772191, Tel: 65-67724518 / 65-67723478, Email:

出版信息

J Nutr Health Aging. 2021;25(3):295-301. doi: 10.1007/s12603-020-1526-x.

Abstract

OBJECTIVES

Experimental evidence suggest that tea polyphenols have anti-depressant effect and tea consumption may reduce the risk and severity of depression. We investigated whether tea consumption was associated with changes in depressive symptoms over time among Asian older adults.

DESIGN

Population-based prospective cohort study with mean 4 years of follow up.

SETTING

Singapore Longitudinal Ageing Study (SLAS) of community-living older persons.

PARTICIPANTS

3177 participants overall (mean age 67 years) and 3004 participants who were depression-free at baseline.

MEASUREMENTS

Baseline tea consumption which include Chinese (black, oolong or green) tea or Western (mixed with milk) tea and change in Geriatric Depression Scale (GDS) measure of depression. Incident depression was defined by GDS≥5, and GDS depression improvement or deterioration by GDS change of ≥4 points. Estimated odds ratio and 95% confidence intervals (OR, 95%CI) were adjusted for baseline age, sex, ethnicity, education, housing type, single/divorced/widowed, living alone, physical and social activity, smoking, alcohol, number of comorbidities, MMSE, and baseline GDS level.

RESULTS

Compared to non-tea drinkers, participants who consumed ≥3 cups of tea of all kinds were significantly less likely to have worsened GDS symptoms: OR=0.32, 95% CI=0.12, 0.84. Among baseline depression-free participants, the risk of incident GDS (≥5) depression was significantly lower (OR=0.34, 95%CI=0.13, 0.90) for daily consumption of all types of tea, and Chinese (black, oolong or green) tea (OR=0.46, 95%CI=0.21,0.99).

CONCLUSION

This study suggests that tea may prevent the worsening of existing depressive symptoms and the reduce the likelihood of developing threshold depression.

摘要

目的

实验证据表明,茶多酚具有抗抑郁作用,饮茶可能降低抑郁的风险和严重程度。我们调查了亚洲老年人的饮茶习惯是否与随时间变化的抑郁症状有关。

设计

具有平均 4 年随访的基于人群的前瞻性队列研究。

地点

居住在社区的老年人新加坡纵向老龄化研究(SLAS)。

参与者

共有 3177 名参与者(平均年龄 67 岁)和 3004 名基线时无抑郁的参与者。

测量方法

基线饮茶情况,包括中国(黑茶、乌龙茶或绿茶)茶或西方(与牛奶混合)茶以及老年抑郁量表(GDS)评估的抑郁变化。通过 GDS≥5 定义为新发抑郁症,GDS 变化≥4 分为 GDS 抑郁改善或恶化。调整了基线年龄、性别、种族、教育程度、住房类型、单身/离婚/丧偶、独居、身体和社会活动、吸烟、饮酒、合并症数量、MMSE 和基线 GDS 水平后,估计比值比和 95%置信区间(OR,95%CI)。

结果

与不饮茶者相比,饮用≥3 杯各种茶的参与者 GDS 症状恶化的可能性显著降低:OR=0.32,95%CI=0.12,0.84。在基线无抑郁的参与者中,每日饮用所有类型的茶和中国(黑茶、乌龙茶或绿茶)茶(OR=0.46,95%CI=0.21,0.99)的风险显著降低(OR=0.34,95%CI=0.13,0.90)。

结论

本研究表明,茶可能预防现有抑郁症状的恶化,并降低发展为阈下抑郁的可能性。

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