Otorhinolaryngological surgical department with a group of head and neck diseases, National Medical Research Center of Children's Health, Moscow, Russia.
Department of ear, nose and throat diseases, Central State Medical Academy, Moscow, Russia.
Laryngoscope. 2021 Aug;131(8):E2475-E2480. doi: 10.1002/lary.29403. Epub 2021 Jan 18.
OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the olfactory status in children with laboratory confirmed SARS-CoV-2 using subjective and psychophysical methods.
Prospective clinical cross-sectional study.
This is a prospective clinical cross-sectional study of 79 children with COVID-19. The 21st item of SNOT-22 questionnaire and odor identification test were used for smell assessment. Children were examined twice during the hospitalization, and a telephone survey was conducted 60 days after hospital discharge.
Immediately after confirmation of COVID-19, smell impairment was detected in 86.1% of children by means of the Identification test and in 68.4% of children by means of the survey (P = .010). After 5 days survey revealed a statistically significant decrease in the number of patients with hyposmia (41 out of 79, 51.9%). On the first visit, the mean Identification test score corresponded to "hyposmia" (9.5 ± 2.7), while on the second visit, the average value was 13.1 ± 1.9, which corresponded to "normosmia." According to the telephone survey, recovery of the olfactory function occurred within 10 days in 37 of 52 patients (71.2%), 11 to 29 days - in 12 children (23.1%), and later than 30 days - in three cases (5.7%).
In the pediatric population, olfactory dysfunction is an early and common symptom of COVID-19. There is a trend to quick recovery of olfactory function in children with COVID-19. The overwhelming majority of patients (94.3%) had no subjective olfactory complaints by the end of the first month.
4 Laryngoscope, 131:E2475-E2480, 2021.
目的/假设：本研究旨在使用主观和心理物理方法评估实验室确诊的 SARS-CoV-2 患儿的嗅觉状况。
前瞻性临床横断面研究。
这是一项针对 79 例 COVID-19 患儿的前瞻性临床横断面研究。使用 SNOT-22 问卷的第 21 项和嗅觉识别测试进行嗅觉评估。患儿在住院期间接受两次检查，并在出院后 60 天进行电话调查。
在 COVID-19 确诊后立即，识别测试发现 86.1%的患儿存在嗅觉障碍，而调查发现 68.4%的患儿存在嗅觉障碍（P=.010）。5 天后的调查显示，嗅觉减退患者的数量有统计学显著下降（79 例中有 41 例，51.9%）。首次就诊时，平均识别测试得分为“嗅觉减退”（9.5±2.7），而第二次就诊时，平均得分为 13.1±1.9，相当于“嗅觉正常”。根据电话调查，52 例中有 37 例（71.2%）患者的嗅觉功能在 10 天内恢复，11-29 天内 12 例（23.1%），30 天后 3 例（5.7%）。
在儿科人群中，嗅觉功能障碍是 COVID-19 的早期常见症状。COVID-19 患儿的嗅觉功能有快速恢复的趋势。在第一个月结束时，绝大多数患者（94.3%）没有主观嗅觉抱怨。
4 Laryngoscope, 131:E2475-E2480, 2021.
