Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing 210008, China.
Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing 210008, China.
ACS Appl Mater Interfaces. 2021 Jan 27;13(3):3547-3558. doi: 10.1021/acsami.0c18841. Epub 2021 Jan 14.
Current tumor immunotherapy has excellent application prospects compared with traditional radiotherapy and chemotherapy, but there are still limitations, such as considerable side effects. This problem can be partially solved by treating the local tumor to induce antitumor immunity. In our study, a novel organic photosensitizer Y8 was used to synthesize nanoparticles (Y8 NPs) via a simple nanoprecipitation method. Further investigation indicated the practical photodynamic and photothermal effects of Y8 NPs with 808 nm laser irradiation. Because of its long-wavelength absorption, Y8 NPs also have excellent imaging effects near-infrared-II region. In metastatic tumor-bearing murine models, Y8 NPs can effectively induce phototherapy, suppressing the growth of both primary and metastatic tumors without apparent systemic toxicity through local photodynamic and photothermal therapy synergistic enhancement of antitumor immunity. This study offers a promising therapeutic strategy for synergetic phototherapy and immunotherapy in tumor treatment.
与传统的放化疗相比，目前的肿瘤免疫疗法具有极好的应用前景，但仍存在一些局限性，如相当大的副作用。通过治疗局部肿瘤来诱导抗肿瘤免疫，可以部分解决这个问题。在我们的研究中，使用一种新型有机光敏剂 Y8 通过简单的纳米沉淀法合成了纳米粒子（Y8 NPs）。进一步的研究表明，Y8 NPs 在 808nm 激光照射下具有实际的光动力和光热效应。由于其长波长吸收，Y8 NPs 在近红外二区也具有优异的成像效果。在转移性肿瘤荷瘤小鼠模型中，Y8 NPs 可通过局部光动力和光热治疗协同增强抗肿瘤免疫，有效诱导光疗，抑制原发和转移性肿瘤的生长，而无明显的全身毒性。本研究为肿瘤治疗中协同光疗和免疫疗法提供了一种有前景的治疗策略。
