Faculty of Dentistry, Graduate Program in Oral Biology, Chulalongkorn University, Bangkok, 10330, Thailand.
Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.
BMC Oral Health. 2024 Oct 4;24(1):1175. doi: 10.1186/s12903-024-04966-4.
Osseointegrated dental implants are widely established as a first-choice treatment for the replacement of missing teeth. Clinical outcomes are however often compromised by short or longer-term biological complications and pathologies. Nanoparticle-coated materials represent a very active research area with the potential to enhance clinical outcomes and reduce complications of implant therapy. This scoping review aimed to summarize current research on various types of nanoparticles (NPs) used as surface modifiers of dental implants and their potential to promote biological and clinical outcomes.
A systematic electronic search was conducted in SCOPUS, PubMed and Google Scholar aiming to identify in vivo, in situ, or in vitro studies published between 2014 and 2024. Inclusion and exclusion criteria were determined and were described in the methods section.
A total of 169 articles (44 original papers from Scopus and PubMed, and 125 articles from Google Scholar) were identified by the electronic search. Finally, 30 studies fit the inclusion criteria and were further used in this review. The findings from the selected papers suggest that nanoparticle-coated dental implants show promising results in enhancing bone regeneration and promoting angiogenesis around the implant site. These effects are due to the unique physicochemical properties of nanoparticle-coated implants and the controlled release of bioactive molecules from nanoparticle-modified surfaces.
Nanoscale modifications displayed unique properties which could significantly enhance the properties of dental implants and further accelerate revascularization, and osseointegration while facilitating early implant loading. Yet, since many of these findings were based on in-vitro/in-situ systems, further research is required before such technology reaches clinical application.
骨整合牙科植入物已被广泛确立为缺失牙齿的首选治疗方法。然而，临床结果常常因短期或长期的生物并发症和病理学而受到影响。纳米颗粒涂层材料是一个非常活跃的研究领域，具有提高临床结果和减少植入物治疗并发症的潜力。本范围综述旨在总结目前用于牙科植入物表面修饰的各种类型纳米颗粒（NP）的研究及其促进生物学和临床结果的潜力。
在 SCOPUS、PubMed 和 Google Scholar 中进行了系统的电子搜索，以确定 2014 年至 2024 年期间发表的体内、原位或体外研究。确定了纳入和排除标准，并在方法部分进行了描述。
通过电子搜索共确定了 169 篇文章（Scopus 和 PubMed 中的 44 篇原始论文，以及 Google Scholar 中的 125 篇文章）。最后，有 30 项研究符合纳入标准，并在本综述中进一步使用。从选定论文中得出的结论表明，纳米颗粒涂层牙科植入物在增强骨再生和促进植入部位周围血管生成方面显示出有希望的结果。这些效果归因于纳米颗粒涂层植入物的独特物理化学性质和纳米颗粒改性表面上生物活性分子的受控释放。
纳米级修饰显示出独特的性质，可显著增强牙科植入物的性能，进一步加速再血管化和骨整合，同时促进早期植入物加载。然而，由于这些发现中的许多是基于体外/原位系统，因此在这种技术达到临床应用之前，还需要进一步的研究。
