Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Int J Mol Sci. 2021 Jan 12;22(2):676. doi: 10.3390/ijms22020676.
Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock.
每个生物体都有内在的生物节律，通过核心和外周组织（包括免疫细胞、血管和血管周围脂肪组织）中的分子时钟网络来协调生物过程以适应日常环境变化。最近的研究发现，生物钟与心血管疾病之间存在很强的相关性。生物钟与身体代谢之间的失同步会导致包括动脉硬化和血栓形成在内的心血管疾病的发展。生物钟参与控制炎症过程和新陈代谢，这会影响动脉硬化和血栓形成的病理。时钟基因在维持昼夜变化与心血管系统之间的强健关系中至关重要。血管系统中的生物钟机制可能是预防和治疗心血管疾病的新的治疗靶点。关于心血管疾病中生物钟的研究仍在不断发展。在这篇综述中，我们简要总结了最近关于生物钟和心血管稳态的研究，重点介绍了生物钟对炎症过程和新陈代谢的控制。基于最近的发现，我们讨论了通过靶向生物钟作为未来针对心血管疾病的治疗策略的潜在靶标分子。
