Department of Biotechnology, Maharishi Markandeshwar (deemed to be University), Mullana, Ambala-133207, Haryana, India.
Pharm Pat Anal. 2021 Jan;10(1):37-49. doi: 10.4155/ppa-2020-0026. Epub 2021 Jan 15.
There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent - aside from its utilization in dealing with conditions like autism, bone and skin improvement and microbial infections, lipid-related illnesses, and so on. XN is reported to suppress the uncontrolled production of inflammatory mediators responsible for diseases including cardiovascular disease, neurodegeneration and tumors. Further, it is accounted to limit adipogenesis and control obesity by focusing on principal adipocyte marker proteins. It is most generally utilized in the brewing industry as an additive and flavoring agent to add bitterness and aroma to beer. Present investigation sum up the patents filed in most recent 2 years on development of different pharmaceutical mixes and strategies dependent on various therapeutic potentials of XN.
越来越多的证据表明，植物中发现的某些天然化合物具有额外的传统药用特性。其中一种化合物是黄腐酚（XN），它被探索作为一种抗菌、抗癌、抗糖尿病和抗炎剂——除了用于治疗自闭症、改善骨骼和皮肤以及微生物感染、与脂质相关的疾病等疾病外。XN 被报道可以抑制负责心血管疾病、神经退行性疾病和肿瘤等疾病的炎症介质的失控产生。此外，它通过专注于主要脂肪细胞标记蛋白来限制脂肪生成并控制肥胖。它最常用于酿造行业，作为添加剂和调味剂，为啤酒增添苦味和香气。目前的研究总结了过去 2 年中提交的关于基于 XN 不同治疗潜力的不同药物组合和策略的专利。
