Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S205-13. doi: 10.1002/mnfr.200900314.
Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 microM). In contrast, XN doses as high as 50 microM did not impair viability of primary human hepatocytes. However, in both cell types XN inhibited activation of the transcription factor NFkappaB and expression of NFkappaB dependent proinflammatory genes. In vivo, feeding of XN reduced hepatic inflammation and expression of profibrogenic genes in a murine model of non-alcoholic steatohepatitis. These data indicate that XN has the potential as functional nutrient for the prevention or treatment of non-alcoholic steatohepatitis or other chronic liver disease.
黄腐酚（XN）是一种存在于啤酒花中的主要类异戊二烯查尔酮，用于增加啤酒的苦味和风味。在这项研究中，我们首先研究了 XN 对肝细胞和肝星状细胞（HSC）的影响，HSC 是肝纤维化的主要中介物。XN 以剂量依赖的方式抑制原代人 HSC 的激活，并诱导活化的 HSC 凋亡（0-20 μM）。相比之下，高达 50 μM 的 XN 剂量不会损害原代人肝细胞的活力。然而，在这两种细胞类型中，XN 均抑制转录因子 NFkappaB 的激活和 NFkappaB 依赖性促炎基因的表达。在体内，XN 的喂养可减少非酒精性脂肪性肝炎小鼠模型中的肝炎症和纤维化基因的表达。这些数据表明，XN 具有作为功能性营养素预防或治疗非酒精性脂肪性肝炎或其他慢性肝病的潜力。
