Athens Medical School, University of Athens, Athens, Greece; Research Institute for Longevity and Aging-related diseases, Athens, Greece.
Athens Medical School, University of Athens, Athens, Greece; Research Institute for Longevity and Aging-related diseases, Athens, Greece.
J Am Coll Cardiol. 2021 Jan 19;77(2):189-204. doi: 10.1016/j.jacc.2020.11.023.
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.
心血管衰老和长寿通过许多病理生理机制相互关联。促进动脉粥样硬化性心血管疾病的许多因素也与衰老过程有关，反之亦然。事实上，代谢紊乱如高血糖、胰岛素抵抗、血脂异常和动脉高血压与衰老和长寿有着共同的病理生理机制。此外，长寿的遗传调节剂对心血管衰老有重大影响。目前关于衰老的遗传、分子和生化途径的知识可以作为引入干预措施的基础，这些干预措施可能延缓心血管衰老，从而实现长寿的目标。在这篇综述中，作者描述了心血管衰老和长寿之间的病理生理联系，并通过报告长寿人群的遗传、饮食和环境特征，将这些机制转化为临床数据。
