On the utility of CSF1R inhibitors.
作者信息
Green Kim N, Hume David A
机构信息
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;
Mater Research Institute, University of Queensland, Woolloongabba, Qld 4102, Australia
出版信息
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). doi: 10.1073/pnas.2019695118.
Abstract
摘要
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A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.一种报告CSF1R蛋白表达的转基因品系为小鼠单核吞噬细胞系统提供了一个明确的标志物。
J Immunol. 2020 Dec 1;205(11):3154-3166. doi: 10.4049/jimmunol.2000835. Epub 2020 Nov 2.
2
CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages.小分子抑制剂对 CSF1R 的抑制作用并非特异性针对小胶质细胞，还会影响造血和巨噬细胞的功能。
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23336-23338. doi: 10.1073/pnas.1922788117. Epub 2020 Sep 8.
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To Kill a Microglia: A Case for CSF1R Inhibitors.杀死小胶质细胞：CSF1R 抑制剂的案例。
Trends Immunol. 2020 Sep;41(9):771-784. doi: 10.1016/j.it.2020.07.001. Epub 2020 Aug 10.
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Nat Commun. 2019 Aug 21;10(1):3758. doi: 10.1038/s41467-019-11674-z.
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Phenotypic impacts of CSF1R deficiencies in humans and model organisms.CSF1R 缺乏在人类和模式生物中的表型影响。
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