维生素 D 补充剂治疗偏头痛的疗效：随机对照研究的荟萃分析。
The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies.
机构信息
Department of Neurology, Daping Hospital, Army Medical University, Chongqing, China.
出版信息
Clin Neuropharmacol. 2021;44(1):5-8. doi: 10.1097/WNF.0000000000000419.
INTRODUCTION
The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.
METHODS
We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.
RESULTS
Five randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, vitamin D treatment is associated with substantially reduced number of headache days (standard mean difference [SMD], -0.53; 95% confidence interval [CI], -0.83 to -0.23; P = 0.0006), frequency of headache attacks (SMD, -1.09; 95% CI, -1.86 to -0.32; P = 0.006), headache severity (SMD, -0.55; 95% CI, -0.91 to -0.19; P = 0.0003), and Migraine Disability Assessment score (SMD, -0.76; 95% CI, -1.11 to -0.40; P < 0.0001).
CONCLUSIONS
Vitamin D treatment is effective to alleviate migraine.
简介
维生素 D 治疗偏头痛的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨维生素 D 与安慰剂对偏头痛患者治疗的影响。
方法
我们通过检索 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，截至 2020 年 4 月，评估了维生素 D 与安慰剂对偏头痛患者治疗效果的随机对照试验。本荟萃分析采用随机效应模型进行。
结果
共有 5 项随机对照试验纳入荟萃分析。总体而言，与对照组相比，维生素 D 治疗可显著减少偏头痛患者的头痛天数（标准均数差 [SMD]，-0.53；95%置信区间 [CI]，-0.83 至 -0.23；P = 0.0006）、头痛发作频率（SMD，-1.09；95% CI，-1.86 至 -0.32；P = 0.006）、头痛严重程度（SMD，-0.55；95% CI，-0.91 至 -0.19；P = 0.0003）和偏头痛残疾评估评分（SMD，-0.76；95% CI，-1.11 至 -0.40；P < 0.0001）。
结论
维生素 D 治疗可有效缓解偏头痛。
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