对肠道微生物群成员用于管理肥胖及相关代谢紊乱的有效性进行全面系统评价。
A comprehensive systematic review of the effectiveness of , a member of the gut microbiome, for the management of obesity and associated metabolic disorders.
作者信息
Roshanravan Neda, Bastani Sepideh, Tutunchi Helda, Kafil Behnam, Nikpayam Omid, Mesri Alamdari Naimeh, Hadi Amir, Sotoudeh Simin, Ghaffari Samad, Ostadrahimi Alireza
机构信息
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Arch Physiol Biochem. 2023 Jun;129(3):741-751. doi: 10.1080/13813455.2021.1871760. Epub 2021 Jan 15.
AIMS AND BACKGROUND
Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, has been proposed as a promising microbe to manage obesity. In the present systematic review, we evaluated evidence on the effectiveness and mechanisms of action of supplementation in the management of obesity.
METHODS
Electronic databases of MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar were searched thought March 2020 to identify relevant published articles, and eligible articles were systematically reviewed.
RESULTS AND CONCLUSIONS
Fifteen studies were included in the present study. Findings from the present review, which included human and animal (rodent) models support the effectiveness of supplementation as a novel therapeutic approach for the management of obesity and metabolic complications associated with obesity. However, future clinical trials are warranted to verify these outcomes.
目的与背景
肥胖被公认为是全球一项重大的公共卫生负担。最近，肠道微生物群与肥胖之间的相互作用备受关注。为此，[某种微生物名称]已被提议作为一种有望控制肥胖的微生物。在本系统评价中，我们评估了补充[某种微生物名称]在肥胖管理中的有效性及作用机制的证据。
方法
检索了MEDLINE、PubMed、Scopus、Web of Science和谷歌学术等电子数据库，直至2020年3月，以识别相关已发表文章，并对符合条件的文章进行系统评价。
结果与结论
本研究纳入了15项研究。本综述的结果，包括人类和动物（啮齿动物）模型，支持补充[某种微生物名称]作为一种治疗肥胖及与肥胖相关代谢并发症的新型治疗方法的有效性。然而，未来有必要进行临床试验以验证这些结果。
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