Leigh T J, Hindmarch I, Bird H A, Wright V
Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, North Yorkshire.
Ann Rheum Dis. 1988 Jan;47(1):40-2. doi: 10.1136/ard.47.1.40.
A sleep laboratory comparison of the sleep of 14 osteoarthritic patients with that of 16 age and sex matched healthy controls was undertaken. After three nights of adaptation continuous recordings of electroencephalographic (EEG), electro-oculographic (EOG), and electromyographic (EMG) activity were obtained for the next two nights. A comparison of EEG sleep variables during this baseline period showed that osteoarthritic patients had a significantly greater percentage of stage 1 and significantly smaller percentage of stage 2 sleep than control subjects. These findings indicate sleep disturbance in osteoarthritic patients. The limited degree of disturbance observed in these patients may be due to the fact that they were allowed to continue with their normal anti-inflammatory and analgesic medication for the course of the study.
对14名骨关节炎患者与16名年龄和性别相匹配的健康对照者的睡眠进行了睡眠实验室比较。在适应的三个晚上之后，接下来的两个晚上连续记录脑电图（EEG）、眼电图（EOG）和肌电图（EMG）活动。在此基线期内对EEG睡眠变量的比较表明，骨关节炎患者的1期睡眠百分比显著更高，而2期睡眠百分比显著低于对照受试者。这些发现表明骨关节炎患者存在睡眠障碍。在这些患者中观察到的有限程度的障碍可能是由于在研究过程中允许他们继续服用常规的抗炎和止痛药物。
