Elling F, Pedersen K B, Høgh P, Foged N T
University Institute of Pathological Anatomy, Copenhagen, Denmark.
APMIS. 1988 Jan;96(1):50-5. doi: 10.1111/j.1699-0463.1988.tb05267.x.
The dermonecrotic effect of purified Pasteurella multocida toxin (PMT) was studied sequentially in guinea pigs and rats. The skin reaction was initially an acute inflammatory reaction, with edema and emigration of neutrophils and a few eosinophils and diapedesis of some erythrocytes. Four hours after intracutaneous injection the vessels were congested and thrombocytes were focally attached to the endothelial wall. Twenty-four h after the injection the inflammatory reaction appeared more severe and venules and arterioles were thrombosed. Necrotic changes were seen in hair follicles and in striated muscle fibers. Crude extracts from P. multocida and Clostridium perfringens injected intracutaneously into guinea pigs induced skin lesions qualitatively similar to the lesions induced by the purified PMT, indicating that dermonecrotic bacterial toxins may share similar biochemical properties.
在豚鼠和大鼠中对纯化的多杀巴斯德菌毒素（PMT）的皮肤坏死作用进行了系列研究。皮肤反应最初是急性炎症反应，伴有水肿、中性粒细胞和少量嗜酸性粒细胞的移出以及一些红细胞的渗出。皮内注射4小时后，血管充血，血小板局部附着在内皮壁上。注射24小时后，炎症反应更为严重，小静脉和小动脉形成血栓。在毛囊和横纹肌纤维中可见坏死变化。将多杀巴斯德菌和产气荚膜梭菌的粗提物皮内注射到豚鼠体内，诱发的皮肤病变在性质上与纯化的PMT诱发的病变相似，这表明皮肤坏死性细菌毒素可能具有相似的生化特性。
