Wardley-Smith B, Little H J, Halsey M J
Clinical Research Centre, Harrow, Middlesex.
Br J Anaesth. 1988 Feb;60(2):140-5. doi: 10.1093/bja/60.2.140.
Using Sprague-Dawley rats, the anti-convulsant potencies of Althesin, ketamine and methohexitone were determined for bicuculline-and strychnine-induced seizures and compared with their effects on hyperbaric seizures. All three anaesthetics protected against both types of chemical convulsants; the degree of protection varied from 34 to 151%, with Althesin being the most effective. However, there was no correlation between their anti-convulsant and anaesthetic potencies, and no relationship between the effects on chemical convulsions and the interactions of the same agents with hyperbaric convulsions. These data suggest that the order of anti-convulsant potencies at equivalent anaesthetic concentration is Althesin much greater than ketamine = methohexitone, and that neither bicuculline-nor strychnine-induced seizures are a good model for hyperbaric convulsions.
使用斯普拉格-道利大鼠，测定了阿法沙龙、氯胺酮和美索比妥对荷包牡丹碱和士的宁诱发癫痫的抗惊厥效力，并将其与它们对高压惊厥的影响进行比较。所有三种麻醉剂都对两种化学惊厥剂有保护作用；保护程度从34%到151%不等，其中阿法沙龙最有效。然而，它们的抗惊厥效力和麻醉效力之间没有相关性，对化学惊厥的影响与相同药物对高压惊厥的相互作用之间也没有关系。这些数据表明，在等效麻醉浓度下，抗惊厥效力的顺序为阿法沙龙远大于氯胺酮=美索比妥，并且荷包牡丹碱或士的宁诱发的癫痫都不是高压惊厥的良好模型。
