Shearer A J, Ross J A, Manson H J
Br J Anaesth. 1981 May;53(5):455-61. doi: 10.1093/bja/53.5.455.
General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, ketamine or methohexitone was estimated by their ability to remain upright in a rotating drum. At 35 atm abs. duration of action was significantly reduced: P less than 0.05 for Althesin; P less than 0.01 for ketamine and methohexitone. A number of animals in each group, however, displayed recovery times that were comparable to control. The convulsion rate with methohexitone was 60% at 35 atm abs., whereas at 1 atm abs. it was 20%. The clinical implications of these findings are discussed.
在加压居住舱中进行急诊手术的全身麻醉可能会使用静脉注射药物。已知此类药物的麻醉特性会受到压力的拮抗，但其对作用持续时间的影响却难以预测。通过小鼠在转鼓中保持直立的能力来评估单次静脉注射阿法沙龙、氯胺酮或甲己炔巴比妥后小鼠的恢复情况。在绝对压力35个大气压时，作用持续时间显著缩短：阿法沙龙P<0.05；氯胺酮和甲己炔巴比妥P<0.01。然而，每组中的一些动物显示出与对照组相当的恢复时间。在绝对压力35个大气压时，甲己炔巴比妥的惊厥率为60%，而在绝对压力1个大气压时为20%。讨论了这些发现的临床意义。
