Kraunak P, Pleuvry B J, Rees J M
Br J Anaesth. 1977 Aug;49(8):765-70. doi: 10.1093/bja/49.8.765.
The interactions of four anaesthetic drugs (ketamine, propanidid, Althesin and methohexitone) with two neuromuscular blocking agents (suxamethonium and pancuronium) have been investigated. On the isolated rat phrenic nerve-diaphragm preparation, all the anaesthetic drugs examined potentiated suxamethonium more than they potentiated pancuronium. The anticholinesterase agent, ecothiopate, had no significant effect on the potentiation of suxamethonium caused by the anaesthetic drugs. At low concentrations the anaesthetic drugs increased the twitch tension elicited by stimulation of the phrenic nerve, whilst at high concentrations this potentiation was followed by blockade of neuromuscular transmission. With the exception of Althesin, all the anaesthetics decreased the sensitivity of the frog rectus preparation to acetylcholine. The possible sites and mechanisms of these interactions are discussed.
研究了四种麻醉药物（氯胺酮、丙泮尼地、阿耳忒辛和甲己炔巴比妥）与两种神经肌肉阻滞剂（琥珀酰胆碱和泮库溴铵）之间的相互作用。在离体大鼠膈神经-膈肌标本上，所有检测的麻醉药物增强琥珀酰胆碱的作用比增强泮库溴铵的作用更明显。抗胆碱酯酶药依可碘酯对麻醉药物引起的琥珀酰胆碱增强作用无显著影响。低浓度时，麻醉药物增加膈神经刺激引起的抽搐张力，而高浓度时，这种增强作用之后是神经肌肉传递的阻滞。除阿耳忒辛外，所有麻醉药均降低蛙腹直肌标本对乙酰胆碱的敏感性。讨论了这些相互作用的可能部位和机制。
