Veering B T, Burm A G, Spierdijk J
Department of Anesthesiology, University Hospital, Leiden, The Netherlands.
Br J Anaesth. 1988 Feb;60(2):187-94. doi: 10.1093/bja/60.2.187.
Effects of ageing were studied on the neural blockade and the pharmacokinetics after subarachnoid administration of 0.5% bupivacaine 3 ml in 8% glucose in two groups of 15 male patients, between 20 and 55 yr and older than 55 yr, respectively. The blockade was performed with the patient in the sitting position. Two minutes after the injection the patient was placed in the supine position. The time to maximum cephalad spread and the upper level of analgesia increased with advancing age, whereas the time to onset of motor blockade decreased with advancing age. Effects of age on the total duration of analgesia and motor blockade could not be demonstrated. Age had no effect on the peak plasma concentration of bupivacaine. The time to peak concentration and the terminal half-life increased, whereas the total plasma clearance decreased with advancing age.
分别在两组各15名男性患者中研究了年龄对蛛网膜下腔注射3ml 0.5%布比卡因加8%葡萄糖后神经阻滞及药代动力学的影响，两组患者年龄分别在20至55岁之间以及55岁以上。阻滞操作时患者取坐位。注射后两分钟将患者置于仰卧位。随着年龄增长，向头侧最大扩散时间及镇痛上界增加，而运动阻滞起效时间随年龄增长而缩短。未证实年龄对镇痛和运动阻滞总时长的影响。年龄对布比卡因血浆峰浓度无影响。随着年龄增长，达峰时间和终末半衰期延长，而总血浆清除率降低。
