Das Dharani, Kulkarni Sunil, Barton-Maclaren Tara, Zhu Jiping
Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
Emerging Approaches Unit, Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, Canada.
Environ Pollut. 2021 Mar 15;273:116457. doi: 10.1016/j.envpol.2021.116457. Epub 2021 Jan 7.
Limited human exposure and toxicity data are currently available for 4,5,6,7-Tetrabromo-2,3-dihydro-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-1H-indene (OBTMPI), a flame retardant often used for high temperature application of various polymer materials. Levels of OBTMPI in a cohort population that includes children and their co-residing parents (n = 217) in Canada were determined. Detection frequency of OBTMPI in the samples was 22.6%. OBTMPI levels were in general at sub-to low ng/g lipid weight level with a 95th percentile at 15.6 ng/g lipid weight. Compared to an earlier study conducted in 2008-2009 in the same region, results from this study show an increase in both detection frequency and concentration of OBTMPI. In silico toxicity predictions using Multicase CaseUltra and Leadscope Model Applier suggested that OBTMPI, and its possible metabolites in humans, while unlikely to be carcinogenic or mutagenic, exhibit some estrogen antagonist, androgen antagonist and estrogen binding capability reflective of possible endocrine disrupting properties.
4,5,6,7-四溴-2,3-二氢-1,1,3-三甲基-3-(2,3,4,5-四溴苯基)-1H-茚(OBTMPI)是一种常用于各种聚合物材料高温应用的阻燃剂，目前关于其人体暴露和毒性的数据有限。对加拿大一个包括儿童及其同住父母在内的队列人群(n = 217)中的OBTMPI水平进行了测定。样本中OBTMPI的检出频率为22.6%。OBTMPI水平一般处于亚纳克/克脂质重量至低纳克/克脂质重量水平，第95百分位数为15.6纳克/克脂质重量。与2008 - 2009年在同一地区进行的早期研究相比，本研究结果显示OBTMPI的检出频率和浓度均有所增加。使用Multicase CaseUltra和Leadscope Model Applier进行的计算机毒性预测表明，OBTMPI及其在人体内可能的代谢产物虽然不太可能具有致癌性或致突变性，但具有一些雌激素拮抗剂、雄激素拮抗剂和雌激素结合能力，反映出可能具有内分泌干扰特性。
