帕金森病患者的运动计划受损。

Motor planning is impaired in Parkinson's disease.

作者信息

Rogers M W, Chan C W

机构信息

School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, Que., Canada.

出版信息

Brain Res. 1988 Jan 12;438(1-2):271-6. doi: 10.1016/0006-8993(88)91346-7.

DOI:10.1016/0006-8993(88)91346-7

PMID:3345432

Abstract

Reaction times (RTs) were assessed in parkinsonian and normal subjects under simple ballistic (bRT), simple tracking (tRT), and choice tracking (CRT) ankle plantarflexion RT paradigms. While RTs were prolonged in both groups for tracking versus bRT movements, between-group differences were not detectable for the simple RT (either ballistic or tracking) tasks. In contrast, parkinsonians demonstrated significantly greater CRT and CRT-bRT delays than normals, suggesting that parkinsonian akinesia may involve a disturbance in central processing related to motor planning.

摘要

在简单弹道式（bRT）、简单跟踪式（tRT）和选择跟踪式（CRT）踝关节跖屈反应时范式下，对帕金森病患者和正常受试者的反应时间（RTs）进行了评估。虽然两组在跟踪运动与弹道式运动时的反应时间均延长，但在简单反应时（弹道式或跟踪式）任务中未检测到组间差异。相比之下，帕金森病患者的选择跟踪式反应时和选择跟踪式反应时与弹道式反应时的延迟显著大于正常人，这表明帕金森病性运动不能可能涉及与运动计划相关的中枢处理紊乱。