Department of Trauma and Orthopaedic Surgery, AOU San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, 84131 Salerno, Italy.
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Br Med Bull. 2021 Jun 10;138(1):58-67. doi: 10.1093/bmb/ldaa040.
Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing.
A systematic search of different databases to October 2020 identified 17 suitable studies.
SiRNAs can be useful to study reparative processes of tendons and identify possible therapeutic targets in tendon healing.
Many genes and growth factors involved in the processes of tendinopathy and tendon healing can be regulated by siRNAs. It is however unclear which gene silencing determines the expected effect.
Gene dysregulation of growth factors and tendon structural proteins can be influenced by siRNA.
It is not clear whether there is a direct action of the siRNAs that can be used to facilitate the repair processes of tendons.
肌腱发生和肌腱稳态由编码肌腱纤维结构分子的基因指导。因此，小干扰 RNA（siRNA）通过基因调控发挥作用，可以参与肌腱愈合的过程。
系统检索了不同的数据库，截至 2020 年 10 月，共确定了 17 项合适的研究。
siRNA 可用于研究肌腱的修复过程，并确定肌腱愈合中可能的治疗靶点。
许多参与肌腱病和肌腱愈合过程的基因和生长因子都可以通过 siRNA 进行调节。然而，尚不清楚哪种基因沉默决定了预期的效果。
生长因子和肌腱结构蛋白的基因失调可以受到 siRNA 的影响。
尚不清楚 siRNA 是否具有可用于促进肌腱修复过程的直接作用。
