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Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

作者信息

Tigyi Gábor, Dacheux Mélanie A, Lin Kuan-Hung, Yue Junming, Norman Derek, Benyó Zoltán, Lee Sue Chin

机构信息

Department of Physiology, University of Tennessee Health Science Center Memphis, 3 N. Dunlap Street, Memphis, TN, 38163, USA.

Department of Pathology, University of Tennessee Health Science Center Memphis, 3 N. Dunlap Street, Memphis, TN, 38163, USA.

出版信息

Cancer Metastasis Rev. 2021 Mar;40(1):3-5. doi: 10.1007/s10555-021-09955-5.

DOI:10.1007/s10555-021-09955-5
PMID:33454844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7897189/
Abstract
摘要

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LPA Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.LPA 是一种抑制性受体，通过破坏早期 TCR 信号转导来抑制 CD8+T 细胞的细胞毒性功能。
Front Immunol. 2019 May 28;10:1159. doi: 10.3389/fimmu.2019.01159. eCollection 2019.
2
A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.基质溶脂素-自分泌运动因子信号轴促进胰腺肿瘤进展。
Cancer Discov. 2019 May;9(5):617-627. doi: 10.1158/2159-8290.CD-18-1212. Epub 2019 Mar 5.
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LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors.LPA4 介导体血管网络形成增加了抗 PD-1 疗法对脑肿瘤的疗效。
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Adv Biol Regul. 2019 Jan;71:183-193. doi: 10.1016/j.jbior.2018.09.008. Epub 2018 Sep 16.
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