Department of Sports Medicine, First Hospital of Jilin University, Changchun 130021, P. R. China.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):5181-5190. doi: 10.1021/acsbiomaterials.0c00662. Epub 2020 Aug 12.
Titanium alloy prostheses have been widely used for the treatment of orthopedic diseases, in which the interconnected porosity and appropriate pore size are crucial for the osseointegration capacity. Three-dimensional (3D) printing technology provides an efficient method to construct prosthesis scaffolds with controllable internal and surface structure, but printing high-porosity (>60%) scaffolds with pore diameters below 300 μm as implants structures has not yet been studied. In this work, four types of titanium alloy scaffolds with interconnected porosity more than 70% were successfully prepared by selective laser melting (SLM). The actual mean pore sizes of cylindrical scaffolds are 542, 366, 202, and 134 μm. Through the in vitro characterization of the scaffolds, in vivo experiments, and mechanical experiments, it is concluded that as the scaffold pore diameter decreases, the titanium alloy scaffold with diameter of 202 μm has the strongest osseointegration ability and is also the most stable one with the surrounding bone. These findings provide a reference for the clinical pore-size design of porous scaffolds with optimal bone growth stability on the surface of the titanium alloy implant.
钛合金假体已被广泛应用于骨科疾病的治疗，其中相互连通的孔隙率和适当的孔径对于骨整合能力至关重要。三维（3D）打印技术为构建具有可控内部和表面结构的假体支架提供了一种高效的方法，但打印具有低于 300μm 孔径的高孔隙率（>60%）支架作为植入物结构尚未得到研究。在这项工作中，通过选择性激光熔化（SLM）成功制备了四种具有超过 70%连通孔隙率的钛合金支架。圆柱形支架的实际平均孔径分别为 542、366、202 和 134μm。通过支架的体外特性表征、体内实验和力学实验得出结论，随着支架孔径的减小，直径为 202μm 的钛合金支架具有最强的骨整合能力，并且与周围骨骼的稳定性也最强。这些发现为临床多孔支架的孔径设计提供了参考，以实现钛合金植入物表面的最佳骨生长稳定性。
