Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1315685981, Iran.
ACS Biomater Sci Eng. 2020 Apr 13;6(4):1852-1873. doi: 10.1021/acsbiomaterials.9b01894. Epub 2020 Mar 10.
Breast cancer is the leading cause of cancer-related mortality among women. Early stage diagnosis and treatment of this cancer are crucial to patients' survival. In addition, it is important to avoid severe side effects during the process of conventional treatments (surgery, chemotherapy, hormonal therapy, and targeted therapy) and increase the patients' quality of life. Over the past decade, nanomaterials of all kinds have shown excellent prospects in different aspects of oncology. Among them, two-dimensional (2D) nanomaterials are unique due to their physical and chemical properties. The functional variability of 2D nanomaterials stems from their large specific surface area as well as the diversity of composition, electronic configurations, interlayer forces, surface functionalities, and charges. In this review, the current status of 2D nanomaterials in breast cancer diagnosis and therapy is reviewed. In this respect, sensing of the tumor biomarkers, imaging, therapy, and theranostics are discussed. The ever-growing 2D nanomaterials are building blocks for the development of a myriad of nanotheranostics. Accordingly, there is the possibility to explore yet novel properties, biological effects, and oncological applications.
乳腺癌是女性癌症相关死亡的主要原因。早期诊断和治疗这种癌症对患者的生存至关重要。此外，在常规治疗（手术、化疗、激素治疗和靶向治疗）过程中避免严重的副作用并提高患者的生活质量也很重要。在过去的十年中，各种纳米材料在肿瘤学的不同方面显示出了极好的前景。其中，二维（2D）纳米材料因其物理和化学性质而具有独特的优势。2D 纳米材料的功能可变性源于其较大的比表面积以及组成、电子构型、层间力、表面官能团和电荷的多样性。在这篇综述中，回顾了 2D 纳米材料在乳腺癌诊断和治疗中的现状。在这方面，讨论了肿瘤生物标志物的传感、成像、治疗和治疗学。不断增长的 2D 纳米材料是开发众多纳米治疗学的基石。因此，有可能探索新的性质、生物学效应和肿瘤学应用。
