Qin Yuning, Lu Humu, Qi Xin, Lin Miaoping, Gao Chenghai, Liu Yonghong, Luo Xiaowei
Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
J Fungi (Basel). 2024 Jan 3;10(1):37. doi: 10.3390/jof10010037.
fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. This review mainly summarizes the sources, chemical structures, and biological activities of 115 recently reported new compounds from the genus from December 2016 to September 2023. They are structurally classified into terpenoids (42%), peptides (29%), polyketides (20%), and others (9%), among which marine sources are predominant (68%). Notably, these compounds were primarily screened with cytotoxic, antibacterial, and anti-inflammatory activities. This paper provides insights into the exploration and utilization of bioactive compounds in this genus, both within the scientific field and pharmaceutical industry.
真菌是丝孢纲中最大且最复杂的属之一，包含130种来自海洋和陆地的菌种。在过去几十年里，对该属各种次生代谢产物进行了大量的化学和生物学研究。迄今为止，已从该属中获得了600多种具有丰富化学类型和广泛生物活性的化合物，引起了化学家和药理学家的相当关注。本综述主要总结了2016年12月至2023年9月该属最近报道的115种新化合物的来源、化学结构和生物活性。它们在结构上分为萜类化合物（42%）、肽类（29%）、聚酮类（20%）和其他（9%），其中海洋来源占主导（68%）。值得注意的是，这些化合物主要针对细胞毒性、抗菌和抗炎活性进行了筛选。本文为该属生物活性化合物在科学领域和制药行业的探索与利用提供了见解。
