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创伤性历史事件对罗马尼亚人口代谢综合征/非酒精性脂肪肝病发病率的跨代影响。

Transgenerational Effects of Traumatic Historical Events on the Incidence of Metabolic Syndrome/ Nonalcoholic Fatty Liver Disease in the Romanian Population.

机构信息

Department of Gastroenterology, "Carol Davila" University of Medicine and Pharmacy", Bucharest, Romania.

Department of Gastroenterology, Fundeni Clinical Institute, Bucharest, Romania.

出版信息

J Med Life. 2020 Oct-Dec;13(4):475-483. doi: 10.25122/jml-2020-0156.

Abstract

Concerns for successful public health management are integrated into the core business of government-responsible institutions. Diseases associated with metabolic syndrome are very common in the Romanian population. In our study, we focused on the cardiovascular and non-alcoholic fatty liver disease (NAFLD). The article starts from the hypothesis that the increased incidence of such diseases is determined today by the cumulative effect of traumatic historical events such as the famine of 1946-47 and the communist political regime specific to the 80s and 90s. This study aims to present the arguments that indicate the correlation of economic variables whose variation can be easily determined by traumatic events that affected the economy, with variables able to measure the incidence of various diseases usually associated with metabolic syndrome or NAFLD. A series of statistical data were analyzed from the official sources available in the form of consecutive value data for the 1995-2018 period. The results highlighted a direct and strong link between the variable gross domestic product (GDP) per capita in USD, 2011 purchasing power parity (PPP) and specific incidence of circulatory, nutritional endocrine and metabolic diseases, as well as a strong and inverse link between GDP and infant's deaths per 1000 live births. Conclusions highlight that the effects of traumatic historical events must be made aware through medical education of the population, supporting the idea according to which the incidence of various metabolic diseases is greater for the offspring of those who have actively suffered during such events.

摘要

对成功的公共卫生管理的关注被纳入政府负责机构的核心业务中。与代谢综合征相关的疾病在罗马尼亚人群中非常普遍。在我们的研究中,我们专注于心血管疾病和非酒精性脂肪肝疾病(NAFLD)。本文从以下假设出发:如今,此类疾病发病率的增加是由 1946-47 年饥荒和 80 年代和 90 年代特有的共产主义政治体制等创伤性历史事件的累积效应所决定的。本研究旨在提出相关论点,表明经济变量的变化与能够衡量通常与代谢综合征或 NAFLD 相关的各种疾病的发生率的变量之间存在相关性,这些经济变量的变化可以通过影响经济的创伤性事件轻松确定。对 1995-2018 年期间可从官方来源以连续值数据形式获得的一系列统计数据进行了分析。结果突出显示了人均国内生产总值(GDP)变量、2011 年购买力平价(PPP)与循环系统、营养内分泌和代谢疾病的特定发病率之间的直接和强联系,以及 GDP 与每千名活产婴儿的婴儿死亡率之间的强负相关。研究结果强调,必须通过对人口进行医学教育来了解创伤性历史事件的影响,支持这样一种观点,即对于那些在这些事件中积极受苦的人的后代,各种代谢疾病的发病率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1877/7803300/0837c6b29e99/JMedLife-13-475-g001.jpg

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