Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Department of Zoology, Faculty of Women for Science, Arts and Education, Ain Shams University, Cairo, Egypt.
Oxid Med Cell Longev. 2020 Dec 15;2020:3178214. doi: 10.1155/2020/3178214. eCollection 2020.
The liver is the most vital organ that could be influenced by inducers of hypersensitivity such as ovalbumin. The current study was carried out to explore the effects of butterbur () extract on the ovalbumin-induced liver hypersensitivity in Swiss albino male mice. Animals were divided into 4 groups, 1 group served as a control group, 2 group treated with daily oral administration of 75 mg/kg of butterbur extract, 3 group received single oral dose 100 mg/kg of ovalbumin to induce hypersensitivity, and 4 group treated with oral administration of butterbur extract one-day post to the hypersensitivity induction. Ovalbumin induces a significant increase in the activity of liver enzymes and MDA and decreased the activity of CAT after the ovalbumin treatment. Histopathological investigations revealed marked pathological alterations in liver tissues in the form of hyaline degeneration and fibrosis. Additionally, heavy immune response indicated by immunostaining of MDA and TNF- could be observed. In contrast, posttreatment with butterbur extract after hypersensitivity induction resulted in a significant decrease of liver enzymes and oxidative stress and reduced the inflammation and fibrosis of liver tissues. These results suggest that butterbur extract is considered as anti-inflammatory and antioxidant therapeutic herb for hypersensitivity treatment of liver.
肝脏是最易受过敏诱导物（如卵清蛋白）影响的重要器官。本研究旨在探讨款冬（）提取物对瑞士白化雄性小鼠卵清蛋白诱导的肝过敏的影响。动物分为 4 组，1 组为对照组，2 组每日口服给予 75mg/kg 的款冬提取物，3 组给予单次口服 100mg/kg 的卵清蛋白以诱导过敏，4 组在过敏诱导后给予口服款冬提取物。卵清蛋白处理后，肝酶和 MDA 活性显著增加，CAT 活性降低。组织病理学检查显示，卵清蛋白处理后肝脏组织出现玻璃样变性和纤维化等明显的病理改变。此外，通过 MDA 和 TNF-的免疫染色可观察到强烈的免疫反应。相反，过敏诱导后给予款冬提取物治疗可显著降低肝酶和氧化应激，并减轻肝脏组织的炎症和纤维化。这些结果表明，款冬提取物被认为是一种具有抗炎和抗氧化作用的治疗过敏的草药。
