Chen Xiaoke, Sun Xinzheng, Wang Chenghao, He Hui
School of Sport Science, Beijing Sport University, 100084, China.
Oxid Med Cell Longev. 2020 Dec 28;2020:6660557. doi: 10.1155/2020/6660557. eCollection 2020.
Inflammation is involved in the pathogenesis of type 2 diabetes (T2DM) and the occurrence of insulin resistance. The purpose of this study was to investigate the effects of exercise on inflammatory factors in patients with T2DM.
A systematic review was conducted on five databases, Cochrane, Embase, Pubmed, Web of Science, and EBSCO. All randomized controlled trials (RCTs) published between establishment of the database and November 2020 without restrictions on language were included. Studies evaluated the effects of exercise intervention on inflammatory cytokines in patients with T2DM were selected.
Twenty-three randomized controlled trials (1350 patients) were included in our meta-analysis. Exercise can significantly reduce the level of C-reactive protein (CRP) (MD: -0.79, 95% CI: -1.26 to -0.33, = 0.0008), tumor necrosis factor- (TNF-) (MD: -2.33, 95% CI: -3.39 to -1.27, < 0.0001), and interleukin-6 (IL-6) (MD: -0.42, 95% CI: -0.60 to -0.24, < 0.0001) in T2DM patients.
The findings of this review suggest that exercise reduces inflammatory cytokines (CRP, TNF-, and IL-6) in T2DM patients. More studies with high methodological qualities and large sample sizes need to be done to confirm which forms of exercise are most effective.
炎症参与2型糖尿病（T2DM）的发病机制及胰岛素抵抗的发生。本研究旨在探讨运动对T2DM患者炎症因子的影响。
对Cochrane、Embase、Pubmed、Web of Science和EBSCO这五个数据库进行系统评价。纳入数据库建立至2020年11月期间发表的所有随机对照试验（RCT），不限语言。选取评估运动干预对T2DM患者炎症细胞因子影响的研究。
我们的荟萃分析纳入了23项随机对照试验（1350例患者）。运动可显著降低T2DM患者的C反应蛋白（CRP）水平（MD：-0.79，95%CI：-1.26至-0.33，P = 0.0008）、肿瘤坏死因子-α（TNF-α）（MD：-2.33，95%CI：-3.39至-1.27，P < 0.0001）和白细胞介素-6（IL-6）（MD：-0.42，95%CI：-0.60至-0.24，P < 0.0001）。
本综述结果表明，运动可降低T2DM患者的炎症细胞因子（CRP、TNF-α和IL-6）。需要开展更多方法学质量高、样本量大的研究，以确定哪种运动形式最有效。
