高场集成磁共振直线加速器放射治疗中肿瘤部位特定的几何畸变

Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy.

作者信息

Hasler Signe Winther, Bernchou Uffe, Bertelsen Anders, van Veldhuizen Elisabeth, Schytte Tine, Hansen Vibeke Nordmark, Brink Carsten, Mahmood Faisal

机构信息

Laboratory of Radiation Physics, Odense University Hospital, Kløvervænget 19, 5000 Odense C, Denmark.

Department of Oncology, Odense University Hospital, Kløvervænget 19, 5000 Odense C, Denmark.

出版信息

Phys Imaging Radiat Oncol. 2020 Aug 19;15:100-104. doi: 10.1016/j.phro.2020.07.007. eCollection 2020 Jul.

DOI:10.1016/j.phro.2020.07.007

PMID:33458333

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7807890/

Abstract

Magnetic resonance imaging (MRI) has exquisite soft-tissue contrast and is the foundation for image guided radiotherapy (IGRT) with integrated magnetic resonance linacs. However, MRI suffers from geometrical distortions. In this study the MRI system- and patient-induced geometric distortion at four different tumor-sites was investigated: adrenal gland (7 patients), liver (4 patients), pancreas (6 patients), prostate (20 patients). Maximum level of total distortion within the gross-tumor-volume (GTV) was 0.96 mm with no significant difference between abdominal patients (adrenal gland, liver, pancreas) and pelvic patients (prostate). Total tumor-site specific distortion depended on location in the field-of-view and increased with the distance to MRI iso-center.

摘要

磁共振成像（MRI）具有出色的软组织对比度，是集成磁共振直线加速器图像引导放射治疗（IGRT）的基础。然而，MRI存在几何畸变。在本研究中，对四个不同肿瘤部位的MRI系统及患者引起的几何畸变进行了研究：肾上腺（7例患者）、肝脏（4例患者）、胰腺（6例患者）、前列腺（20例患者）。大体肿瘤体积（GTV）内的总畸变最大水平为0.96毫米，腹部患者（肾上腺、肝脏、胰腺）和盆腔患者（前列腺）之间无显著差异。总的肿瘤部位特异性畸变取决于在视野中的位置，并随着与MRI等中心距离的增加而增大。