克罗恩病患者小肠对聚乙二醇600的通透性。术中对小肠特定节段的测定。
Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Peroperative determination in a defined segment of the small intestine.
作者信息
Olaison G, Leandersson P, Sjödahl R, Tagesson C
机构信息
Department of Surgery, University Hospital, Linköping, Sweden.
出版信息
Gut. 1988 Feb;29(2):196-9. doi: 10.1136/gut.29.2.196.
Ileal permeability to different sized polyethyleneglycols (590-942 dalton PEG) was investigated peroperatively in 11 patients with Crohn's disease and seven with colonic carcinoma. A 15 cm ileal segment was converted into a tied loop, in which the PEG's were deposited. Absorption from the ileal segment was then measured as six-hour urinary recovery of the PEg dose. Polyethyleneglycol absorption in Crohn's disease was greater than in cancer patients and similar throughout the weight range, but in the cancer patients it was inversely proportional to molecular weight. Thus there was significantly greater absorption of the higher weights (greater than or equal to 678 dalton) in the Crohn's, than in the cancer patients. The apparently increased permeability of the small intestine in Crohn's disease may be an important factor in its pathogenesis.
在手术过程中，对11例克罗恩病患者和7例结肠癌患者的回肠对不同大小的聚乙二醇（590 - 942道尔顿的PEG）的通透性进行了研究。将一段15厘米长的回肠做成一个结扎环，在其中注入PEG。然后通过测量6小时尿液中PEG剂量的回收率来测定回肠段的吸收情况。克罗恩病患者的聚乙二醇吸收量大于癌症患者，并且在整个分子量范围内情况相似，但在癌症患者中，吸收量与分子量成反比。因此，克罗恩病患者对较高分子量（大于或等于678道尔顿）的吸收明显高于癌症患者。克罗恩病中小肠通透性明显增加可能是其发病机制中的一个重要因素。
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