Tayanloo-Beik Akram, Rabbani Zahra, Soveyzi Faezeh, Alavi-Moghadam Sepideh, Rezaei-Tavirani Mostafa, Goodarzi Parisa, Arjmand Babak, Larijani Bagher
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran.
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2021 Feb;48(2):1787-1800. doi: 10.1007/s11033-020-06126-7. Epub 2021 Jan 18.
Spinal cord injury is a serious problem with a high rate of morbidity and mortality for all persons, especially young people (15-25 years old). Due to the large burden and the costs incurred on the government, finding the best therapeutic approach is necessary. In this respect, treatment strategies based on the disease mechanism can be effective. After the first trauma of spinal cord cascades, cellular events happen one after the other known as secondary trauma. The mechanism of secondary events of spinal cord injury could be helpful for target therapy as trying to stop the secondary trauma. Herein, some medical and surgical therapy has been introduced and cell therapy strategy was considered as a recent method. Actually, cell therapy is defined as the application of different cells including mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, and some others to replace or reconstruct the damaged tissues and restore their functions. However, as a newly emerged therapeutic method, cell therapy should be used through various subclinical studies in animal models to assess the efficacy of the treatment under controlled conditions. In this review, the role of Zebrafish as a recommended model has been discussed and combinatory approach as the probably most useful treatment has been suggested.
脊髓损伤是一个严重的问题，对所有人来说发病率和死亡率都很高，尤其是年轻人（15至25岁）。由于其带来的巨大负担以及给政府造成的成本，找到最佳治疗方法很有必要。在这方面，基于疾病机制的治疗策略可能会有效。在脊髓级联反应的首次创伤后，细胞事件相继发生，这被称为继发性创伤。脊髓损伤继发性事件的机制可能有助于靶向治疗，即试图阻止继发性创伤。在此，介绍了一些医学和外科治疗方法，并将细胞治疗策略视为一种最新的方法。实际上，细胞治疗被定义为应用包括间充质干细胞、胚胎干细胞、诱导多能干细胞等不同细胞来替代或重建受损组织并恢复其功能。然而，作为一种新出现的治疗方法，细胞治疗应通过在动物模型中进行的各种亚临床研究来使用，以在可控条件下评估治疗效果。在本综述中，讨论了斑马鱼作为推荐模型的作用，并提出联合方法可能是最有用的治疗方法。
