干细胞与脊髓损伤的串扰：病理生理学与治疗策略。
Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies.
机构信息
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
出版信息
Stem Cell Res Ther. 2019 Aug 6;10(1):238. doi: 10.1186/s13287-019-1357-z.
The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.
受伤的脊髓很难修复和再生。传统的治疗方法效果不佳。干细胞是一种具有分化为多种细胞（包括神经元）潜能的细胞。它们通过安全有效地分化为神经元或替代受损细胞、分泌神经营养因子和抑制炎症反应来发挥治疗作用。已经使用了多种类型的干细胞进行移植，每种类型都有其自身的优点和缺点。本文综述了干细胞治疗脊髓损伤的可能机制，以及实验中常用的干细胞类型，为脊髓损伤的干细胞治疗基础和临床研究提供参考。
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