Department of Laboratory Medicine, University Hospital of North Norway, 9038 Tromsø, Norway; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Department of Laboratory Medicine, University Hospital of North Norway, 9038 Tromsø, Norway; Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway.
Environ Res. 2019 Feb;169:114-121. doi: 10.1016/j.envres.2018.11.005. Epub 2018 Nov 5.
Exposure to environmental pollutants may contribute to the development of asthma and other allergies. The aim of this study was to investigate possible associations between asthma and other allergies with exposure to perfluoroalkyl substances (PFASs) in adolescents from the Arctic region of Norway.
The Tromsø study Fit Futures 1 (TFF1) and 3-year follow-up Fit Futures 2 study (TFF2) included 675 adolescents that completed a questionnaire about health conditions and underwent a clinical examination with blood tests and fractional nitric oxide (FeNO) measurement. Serum concentrations of 18 PFASs were measured by UHPLC-MS/MS method.
Total PFASs (ΣPFAS) serum concentration over 4th quartile was positively associated with asthma in the TFF1 (OR 3.35 (95% CI 1.54-7.29), p = 0.002). Total perfluorooctane sulfonate (ΣPFOS), linear PFOS (linPFOS), linear perfluorohexane sulfonate (linPFHxS) concentrations over 4th quartiles were associated with 2 times higher odds of asthma in the TFF1. The positive associations between ΣPFAS, ΣPFOS, linPFOS and asthma remained statistically significant in the TFF2. ΣPFAS and linPFHxS concentrations over 3rd tertiles were associated with positive marker of eosinophilic airways inflammation FeNO> 25 ppb. Concentrations of ΣPFOS and linPFOS over 3rd quartiles were positively associated with self-reported nickel allergy (OR 2.25 (95% CI 1.17-4.35) p = 0.016 and OR 2.53 (95% CI 1.30-4.90) p = 0.006, respectively). Allergic rhinitis, self-reported pollen allergy, food allergy and atopic eczema were not associated with PFASs concentrations.
This study of Norwegian adolescents showed a positive association between several PFASs and asthma, as well as between PFOS and nickel allergy.
暴露于环境污染物可能会导致哮喘和其他过敏的发生。本研究旨在调查挪威北极地区青少年接触全氟烷基物质（PFASs）与哮喘和其他过敏之间的可能关联。
特罗姆瑟研究未来 1 号（TFF1）和 3 年随访特罗姆瑟研究未来 2 号（TFF2）纳入了 675 名青少年，他们完成了一份关于健康状况的问卷，并接受了临床检查，包括血液测试和分数一氧化氮（FeNO）测量。采用 UHPLC-MS/MS 法测定血清中 18 种 PFASs 的浓度。
TFF1 中，血清全氟烷基物质（ΣPFAS）浓度超过第 4 四分位数与哮喘呈正相关（OR 3.35（95% CI 1.54-7.29），p=0.002）。全氟辛烷磺酸（ΣPFOS）、线性全氟辛烷磺酸（linPFOS）、线性全氟己烷磺酸（linPFHxS）浓度超过第 4 四分位数与 TFF1 中哮喘的 2 倍更高的几率相关。在 TFF2 中，ΣPFAS、ΣPFOS、linPFOS 与哮喘之间的正相关关系仍然具有统计学意义。ΣPFAS 和 linPFHxS 浓度超过第 3 tertiles 与嗜酸性气道炎症的阳性标志物 FeNO>25 ppb 相关。ΣPFOS 和 linPFOS 浓度超过第 3 四分位数与自我报告的镍过敏呈正相关（OR 2.25（95% CI 1.17-4.35），p=0.016 和 OR 2.53（95% CI 1.30-4.90），p=0.006）。过敏性鼻炎、自我报告的花粉过敏、食物过敏和特应性皮炎与 PFASs 浓度无关。
本研究表明，挪威青少年接触多种 PFASs 与哮喘呈正相关，PFOS 与镍过敏呈正相关。
