College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei Province, 071002, PR China.
Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, 050200, PR China.
Colloids Surf B Biointerfaces. 2021 Apr;200:111568. doi: 10.1016/j.colsurfb.2021.111568. Epub 2021 Jan 11.
We report here a self-healing hydrogel with antibacterial and light-emitting properties for wound repair. The hydrogel was prepared by reaction of poly(aspartic acid) (PASP) derivatives bearing groups of quaternary ammonium and boronic acid with poly(vinyl alcohol) (PVA). Due to the dynamic nature of boronic ester bonds, bacteria-killing activity of quaternary ammonium, and light-emitting activity of phenylboronic ester, the resultant hydrogels featured self-healing, antibacterial and light-emitting properties. The hydrogels show controlled release behavior of mouse epidermal growth factor (mEGF) and the in vivo studies show mEGF loaded hydrogel accelerate the wound repair of model mice and improve skin cell proliferation by prevention of bacterial infections. The PASP based hydrogels would show great promise in bio-applications, in particular for wound dressing and tissue repairing.
我们在这里报道了一种具有自修复、抗菌和发光性能的水凝胶，可用于伤口修复。该水凝胶是通过带有季铵盐和硼酸基团的聚天冬氨酸（PASP）衍生物与聚乙烯醇（PVA）反应制备的。由于硼酸酯键的动态性质、季铵盐的杀菌活性和苯硼酸酯的发光活性，所得水凝胶具有自修复、抗菌和发光性能。水凝胶表现出对小鼠表皮生长因子（mEGF）的控制释放行为，体内研究表明负载 mEGF 的水凝胶通过预防细菌感染加速模型小鼠的伤口愈合并促进皮肤细胞增殖。基于 PASP 的水凝胶在生物应用方面具有很大的应用前景，特别是在伤口敷料和组织修复方面。
