Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China.
Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
ACS Biomater Sci Eng. 2021 Nov 8;7(11):5135-5143. doi: 10.1021/acsbiomaterials.1c00719. Epub 2021 Oct 11.
Hydrogels with inherent antibacterial ability are a focus in soft tissue repair. Herein, a series of antibacterial hydrogels were fabricated by quaternized -[3-(dimethylamino)propyl] methacrylamide (quaternized P(DMAPMA-DMA-DAA)) bearing copolymers with dithiodipropionic acid dihydrazide (DTDPH) as cross-linker. The hydrogels presented efficient self-healing capability as well as a pH and redox-triggered gel-sol-gel transition property that is based on the dynamic acylhydrazone bond and disulfide linkage. Furthermore, the hydrogels showed good antibacterial activity, biocompatibility, degradability, and sustained release ability. More importantly, the in vivo experiments demonstrated that the hydrogels loaded with mouse epidermal growth factor (mEGF) significantly accelerated wound closure by preventing bacterial infection and promoting cutaneous regeneration in the wound model. The antibacterial hydrogels with self-healing behavior hold great potential in wound treatment.
具有内在抗菌能力的水凝胶是软组织修复的重点。本文通过将带有二硫代二丙酸二酰肼（DTDPH）的共聚物季铵化- [3-（二甲基氨基）丙基]甲基丙烯酰胺（季铵化 P（DMAPMA-DMA-DAA））制备了一系列具有抗菌能力的水凝胶作为交联剂。水凝胶具有高效的自修复能力，以及基于动态酰腙键和二硫键的 pH 值和氧化还原触发的凝胶-溶胶-凝胶转变特性。此外，水凝胶还表现出良好的抗菌活性、生物相容性、可降解性和缓释能力。更重要的是，体内实验表明，载有小鼠表皮生长因子（mEGF）的水凝胶通过防止细菌感染和促进伤口模型中的皮肤再生，显著加速了伤口闭合。具有自修复行为的抗菌水凝胶在伤口治疗方面具有巨大的潜力。
