Department of Community Health Sciences and Department of Production Animal Health, Cumming School of Medicine and Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Department of Medicine, University of Calgary, Room 6D60, TRW Building, 3280 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Sci Rep. 2021 Jan 18;11(1):1674. doi: 10.1038/s41598-020-80924-8.
This study examined associations between dietary intake and gut and systemic inflammation assessed by fecal calprotectin ≤ or > 100 μg/mg (FCP), C-reactive protein ≤ or > 5 mg/L (CRP) and serum cytokine profiles in Crohn's disease (CD) patients in clinical remission. A 3-month observational study was conducted at the University of Calgary in Calgary, Alberta, Canada between 2016 and 2018 in 66 outpatients with CD in clinical remission. FCP was obtained from stool samples at baseline and 3-months and serum CRP and serum cytokines were assessed at 3-months only (n = 41). Dietary intakes were collected using 3-day food records at baseline and 3-months and categorized as: PREDIMED Mediterranean diet scores (pMDS) total and individual components, the dietary inflammatory index (DII), food groups, and common micro- and macro-nutrients. Statistical models were developed to identify relationships between dietary factors and FCP, CRP and cytokine levels. Daily intake of leafy green vegetables was associated with FCP ≤ 100 μg/mg (p < 0.05). Increasing omega 6:3 ratio was associated with CRP ≤ 5 mg/L (p = 0.02). Different cytokines were significantly associated with various dietary variables. Future studies in patients with greater disease activity should be undertaken to explore these relationships.
这项研究旨在探讨在临床缓解期的克罗恩病（CD）患者中，粪便钙卫蛋白（FCP）≤或>100μg/mg（FCP）、C 反应蛋白（CRP）≤或>5mg/L（CRP）和血清细胞因子谱与饮食摄入之间的关系。2016 年至 2018 年期间，在加拿大阿尔伯塔省卡尔加里市的卡尔加里大学进行了一项为期 3 个月的观察性研究，共有 66 名处于临床缓解期的 CD 门诊患者参与。在基线和 3 个月时采集粪便样本检测 FCP，仅在 3 个月时采集血清 CRP 和血清细胞因子（n=41）。采用 3 天食物记录法在基线和 3 个月时收集饮食摄入量，并分为：PREDIMED 地中海饮食评分（pMDS）总分和各成分、饮食炎症指数（DII）、食物组和常见微量及宏量营养素。建立统计模型以确定饮食因素与 FCP、CRP 和细胞因子水平之间的关系。绿叶蔬菜的每日摄入量与 FCP≤100μg/mg 相关（p<0.05）。ω-6:3 比值的增加与 CRP≤5mg/L 相关（p=0.02）。不同的细胞因子与各种饮食变量显著相关。应在疾病活动度更高的患者中开展进一步研究，以探讨这些关系。
