Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671, Athens, Greece.
Norwich Medical School, University of East Anglia, Bob Champion Building, James Watson Road, Norwich, NR4 7UQ, UK.
Eur J Nutr. 2020 Apr;59(3):1115-1121. doi: 10.1007/s00394-019-01972-z. Epub 2019 Apr 20.
To assess the adherence to MD in patients with Crohn's disease (CD).
Outpatients with CD were enrolled in this protocol. Medical history, disease activity, dietary intake, habitual Mediterranean diet (MedDiet) score, anthropometric measurements and Inflammatory Bowel Disease Questionnaire (IBDQ) were recorded. Blood samples were collected for quantification of biochemical and inflammatory indices.
A total of 86 patients with CD were enrolled: 41 in relapse (5 ≤ Harvey Bradshaw Index ≤ 14) and 45 in remission (Harvey Bradshaw Index ≤ 4). Adherence to MD was greater in patients with inactive disease. The MedDiet score correlated positively with the IBDQ (p = 0.008) and negatively with disease activity (p < 0.001).
Adherence to Mediterranean diet is associated with improved quality of life in CD patients. Higher adherence to Mediterranean diet could be of importance in patients with CD to improve quality of life and reduce disease activity.
评估克罗恩病（CD）患者对 MD 的依从性。
本方案纳入了门诊 CD 患者。记录了病史、疾病活动度、饮食摄入、习惯性地中海饮食（MedDiet）评分、人体测量学指标和炎症性肠病问卷（IBDQ）。采集血样以定量检测生化和炎症指标。
共纳入 86 例 CD 患者：41 例处于复发期（5≤Harvey Bradshaw 指数≤14），45 例处于缓解期（Harvey Bradshaw 指数≤4）。无疾病活动患者对 MD 的依从性更高。MedDiet 评分与 IBDQ 呈正相关（p=0.008），与疾病活动呈负相关（p<0.001）。
CD 患者对地中海饮食的依从性与生活质量的改善相关。地中海饮食的更高依从性可能对 CD 患者改善生活质量和降低疾病活动度很重要。
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