Ding Cuicui, Tian Mengdie, Feng Ren, Dang Yuan, Zhang Min
College of Ecological Environment and Urban Construction, Fujian University of Technology, Fuzhou 350108, PR China.
Laboratory of Basic Medicine, 900 Hospital of the Joint Logistics Team (Dongfang Hospital)(Former Fuzhou General Hospital), Xiamen University Medical College, 156 Road Xi'erhuanbei, Fuzhou 350025, Fujian, PR China.
ACS Biomater Sci Eng. 2020 Jul 13;6(7):3855-3867. doi: 10.1021/acsbiomaterials.0c00588. Epub 2020 Jun 18.
Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials. However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks. In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability. Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity. This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
胶原蛋白（COL）-壳聚糖（CS）复合水凝胶因其作为生物材料的巨大应用潜力而受到越来越多的关注。然而，传统的COL-CS水凝胶由于其网络中缺乏完全可逆的连接而容易失效。在这项工作中，我们开发了一种用于伤口敷料的自愈合水凝胶，它由COL、CS和通过动态亚胺键修饰的二苯甲醛聚乙二醇组成，并且COL/CS水凝胶表现出良好的热稳定性、可注射性和pH敏感性，理想地促进了伤口愈合性能和止血能力。此外，该水凝胶可以监测多种人体运动，特别是通过应变敏感性监测面部表情。这项工作为基于生物质的水凝胶在医疗领域作为伤口敷料的应用提供了新的视角。
