State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan 430062, China; Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Hubei University, Wuhan 430062, China.
Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Carbohydr Polym. 2023 Jan 1;299:120198. doi: 10.1016/j.carbpol.2022.120198. Epub 2022 Oct 10.
Promoting the healing of diabetic wounds remains a major challenge in scientific research today. A star-like eight-arm cross-linker octafunctionalized POSS of benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO) was synthesized, and crosslinked with hydroxypropyltrimethyl ammonium chloride chitosan (HACC) via Schiff base reaction to obtain Chitosan-based POSS-PEG hybrid hydrogels. The designed composite hydrogels exhibited strong mechanical strength, injectability, excellent self-healing efficiency, good cytocompatibility and antibacterial properties. Furthermore, the composite hydrogels could accelerate cells migration and proliferation, as expected by remarkably promoting wound healing in diabetic mice. The wounds treated with the composite hydrogels displayed faster regeneration of epithelial tissue, fewer inflammatory cells, more collagen deposition and higher expression level of VEGF. Therefore, Chitosan-based POSS-PEG hybrid hydrogel has great application potential as a dressing for promoting the healing of diabetic wounds.
促进糖尿病伤口愈合仍然是当今科学研究的一大挑战。合成了一种以苯甲醛封端的聚乙二醇（POSS-PEG-CHO）为星型八臂交联剂的八官能化 POSS，并通过席夫碱反应将其与羟丙基三甲基氯化铵壳聚糖（HACC）交联，得到基于壳聚糖的 POSS-PEG 杂化水凝胶。设计的复合水凝胶具有较强的机械强度、可注射性、优异的自修复效率、良好的细胞相容性和抗菌性能。此外，复合水凝胶可以促进细胞迁移和增殖，显著促进糖尿病小鼠伤口愈合。用复合水凝胶处理的伤口显示出更快的上皮组织再生、更少的炎症细胞、更多的胶原蛋白沉积和更高的 VEGF 表达水平。因此，基于壳聚糖的 POSS-PEG 杂化水凝胶作为一种促进糖尿病伤口愈合的敷料具有很大的应用潜力。
