Ximendes Erving, Benayas Antonio, Jaque Daniel, Marin Riccardo
Fluorescence Imaging Group, Departamento de Fısica de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain.
Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Ctra. Colmenar km. 9.100, Madrid 28034, Spain.
ACS Nano. 2021 Feb 23;15(2):1917-1941. doi: 10.1021/acsnano.0c08349. Epub 2021 Jan 19.
The exciting advancements that we are currently witnessing in terms of novel materials and synthesis approaches are leading to the development of colloidal nanoparticles (NPs) with increasingly greater tunable properties. We have now reached a point where it is possible to synthesize colloidal NPs with functionalities tailored to specific societal demands. The impact of this new wave of colloidal NPs has been especially important in the field of biomedicine. In that vein, luminescent NPs with improved brightness and near-infrared working capabilities have turned out to be optimal optical probes that are capable of fast and high-resolution imaging. However, luminescent NPs have thus far only reached a limited portion of their potential. Although we believe that the best is yet to come, the future might not be as bright as some of us think (and have hoped!). In particular, translation of NP-based fluorescence imaging from preclinical studies to clinics is not straightforward. In this Perspective, we provide a critical assessment and highlight promising research avenues based on the latest advances in the fields of luminescent NPs and imaging technologies. The disillusioned outlook we proffer herein might sound pessimistic at first, but we consider it necessary to avoid pursuing "pipe dreams" and redirect the efforts toward achievable-yet ambitious-goals.
我们目前在新型材料和合成方法方面目睹的激动人心的进展，正促使具有越来越大可调谐特性的胶体纳米颗粒（NPs）得到发展。我们现在已经达到了这样一个阶段，即有可能合成具有针对特定社会需求量身定制功能的胶体NPs。这一波新型胶体NPs在生物医学领域的影响尤为重要。在这方面，具有更高亮度和近红外工作能力的发光NPs已成为能够进行快速高分辨率成像的最佳光学探针。然而，发光NPs迄今为止仅发挥了其潜力的有限部分。尽管我们相信最好的还在后头，但未来可能不像我们有些人认为的（并希望的！）那么光明。特别是，基于NP的荧光成像从临床前研究到临床的转化并非一帆风顺。在这篇观点文章中，我们基于发光NPs和成像技术领域的最新进展进行了批判性评估，并突出了有前景的研究途径。我们在此提出的这种不乐观的观点乍一听可能令人沮丧，但我们认为有必要避免追求“白日梦”，并将努力重新导向可实现但雄心勃勃的目标。
