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一种喹啉连接的环糊精衍生物作为核苷酸的高选择性受体和比色探针。

A Quinoline-Appended Cyclodextrin Derivative as a Highly Selective Receptor and Colorimetric Probe for Nucleotides.

作者信息

Kanagaraj Kuppusamy, Xiao Chao, Rao Ming, Fan Chunying, Borovkov Victor, Cheng Guo, Zhou Dayang, Zhong Zhihui, Su Dan, Yu Xingke, Yao Jiabin, Hao Taotao, Wu Wanhua, Chruma Jason J, Yang Cheng

机构信息

Key Laboratory of Green Chemistry & Technology, College of Chemistry, State Key Laboratory of Biotherapy, West China Medical Center, and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610064, China.

College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China.

出版信息

iScience. 2020 Mar 27;23(3):100927. doi: 10.1016/j.isci.2020.100927. Epub 2020 Feb 21.

DOI:10.1016/j.isci.2020.100927
PMID:32169819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7066246/
Abstract

The design and development of specific recognition and sensing systems for biologically important anionic species has received growing attention in recent years, as they play significant roles in biology, pharmacy, and environmental sciences. Herein, a new supramolecular sensing probe L1 was developed for highly selective differentiation of nucleotides. L1 displayed extremely marked absorption and emission differentiation upon binding with nucleotide homologs of AMP, ADP, and ATP, due to the divergent spatial orientations of guests upon binding, which allowed for a naked-eye colorimetric differentiation for nucleotides. A differentiating mechanism was unambiguously rationalized by using various spectroscopic studies and theoretical calculations. Furthermore, we successfully demonstrated that L1 can be applied to the real-time monitoring of the enzyme-catalyzed phosphorylation/dephosphorylation processes and thus demonstrated an unprecedented visualizable strategy for selectively differentiating the structurally similar nucleotides and real-time monitoring of biological processes via fluorescent and colorimetric changes.

摘要

近年来，针对具有生物学重要性的阴离子物种的特定识别和传感系统的设计与开发受到了越来越多的关注，因为它们在生物学、药学和环境科学中发挥着重要作用。在此，开发了一种新的超分子传感探针L1，用于核苷酸的高选择性区分。L1与AMP、ADP和ATP的核苷酸同系物结合时，由于客体结合时不同的空间取向，表现出极其显著的吸收和发射差异，这使得可以通过肉眼比色法区分核苷酸。通过各种光谱研究和理论计算明确地阐释了区分机制。此外，我们成功地证明了L1可应用于酶催化的磷酸化/去磷酸化过程的实时监测，从而展示了一种前所未有的可视化策略，用于通过荧光和比色变化选择性区分结构相似的核苷酸并实时监测生物过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/219a316fbd69/gr11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/d316ef47c2d3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/63c15394a91a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/54b3e101ecbc/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/a0cdb066e565/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/20ca8d945119/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/f358ba54199c/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/219a316fbd69/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/89b281c9df15/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/f32a2931e111/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/b74f2bc8acaa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/da1a5e896711/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/365215dff21e/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/304af1b920e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/07f6facc2a6f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/9bc25fd2704f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/dfdc6ea968e3/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/d316ef47c2d3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/63c15394a91a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/54b3e101ecbc/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/a0cdb066e565/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/20ca8d945119/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/f358ba54199c/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5bd/7066246/219a316fbd69/gr11.jpg

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