National Research Centre, Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, El-Behoos St. 33, Dokki, Cairo 12622, Egypt.
Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Mar Drugs. 2021 Jan 14;19(1):35. doi: 10.3390/md19010035.
Analysis of the air-dried marine red alga , collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (), 7-acetyl-aplysiol (), aplysiol-7-one (), 11,14-dihydroaplysia-5,11,14,15-tetrol (), and a new maneonene derivative , named 5--maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of and . The antimicrobial activities of the crude extract and compounds -, and were studied.
对在埃及苏伊士湾拉斯巴克尔附近采集的风干海洋红藻进行分析，得到了五个新的卤代萜类衍生物：aplysiolic 酸 ()、7-乙酰-aplysiol ()、aplysiol-7-one ()、11,14-二氢-aplysia-5,11,14,15-四醇 ()和一个新的 maneonene 衍生物，命名为 5--maneolactone。这些代谢物的化学结构通过光谱方法进行了表征，并通过比较实验和从头计算 NMR、NOE、ECD 和 ORD 数据以及 和 的 X 射线衍射确定了它们的相对和绝对构型。研究了粗提取物和化合物 - 、- 和 - 的抗菌活性。
