• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

黄单胞菌的HrpG/HrpX调控子——对植物致病细菌毒力性状调控复杂性的洞察

The HrpG/HrpX Regulon of Xanthomonads-An Insight to the Complexity of Regulation of Virulence Traits in Phytopathogenic Bacteria.

作者信息

Teper Doron, Pandey Sheo Shankar, Wang Nian

机构信息

Department of Plant Pathology and Weed Research, Agricultural Research Organization (ARO)-Volcani Center, Rishon LeZion 7505101, Israel.

Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Lake Alfred, FL 33850, USA.

出版信息

Microorganisms. 2021 Jan 16;9(1):187. doi: 10.3390/microorganisms9010187.

DOI:10.3390/microorganisms9010187
PMID:33467109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7831014/
Abstract

Bacteria of the genus cause a wide variety of economically important diseases in most crops. The virulence of the majority of spp. is dependent on secretion and translocation of effectors by the type 3 secretion system (T3SS) that is controlled by two master transcriptional regulators HrpG and HrpX. Since their discovery in the 1990s, the two regulators were the focal point of many studies aiming to decipher the regulatory network that controls pathogenicity in bacteria. HrpG controls the expression of HrpX, which subsequently controls the expression of T3SS apparatus genes and effectors. The HrpG/HrpX regulon is activated and subjected to tight metabolic and genetic regulation. In this review, we cover the advances made in understanding the regulatory networks that control and are controlled by the HrpG/HrpX regulon and their conservation between different spp.

摘要

[该属细菌]在大多数作物中引发了多种具有重要经济意义的疾病。大多数[该属细菌]的毒力取决于III型分泌系统（T3SS）对效应蛋白的分泌和转运，而III型分泌系统由两个主要转录调节因子HrpG和HrpX控制。自20世纪90年代被发现以来，这两个调节因子一直是许多旨在破译控制[该属细菌]致病性的调控网络的研究焦点。HrpG控制HrpX的表达，随后HrpX控制III型分泌系统装置基因和效应蛋白的表达。HrpG/HrpX调控子被激活并受到严格的代谢和遗传调控。在本综述中，我们涵盖了在理解控制HrpG/HrpX调控子以及受其控制的调控网络方面取得的进展，以及它们在不同[该属细菌]之间的保守性。

注

原文中“Bacteria of the genus ”和“ spp.”处因未明确具体属名，所以翻译时保留了英文表述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/a6b008b96413/microorganisms-09-00187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/e3d168cc4ccd/microorganisms-09-00187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/21eb4ef1f7da/microorganisms-09-00187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/a6b008b96413/microorganisms-09-00187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/e3d168cc4ccd/microorganisms-09-00187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/21eb4ef1f7da/microorganisms-09-00187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053c/7831014/a6b008b96413/microorganisms-09-00187-g003.jpg

相似文献

1
The HrpG/HrpX Regulon of Xanthomonads-An Insight to the Complexity of Regulation of Virulence Traits in Phytopathogenic Bacteria.黄单胞菌的HrpG/HrpX调控子——对植物致病细菌毒力性状调控复杂性的洞察
Microorganisms. 2021 Jan 16;9(1):187. doi: 10.3390/microorganisms9010187.
2
Comparative transcriptomics reveals a highly polymorphic Xanthomonas HrpG virulence regulon.比较转录组学揭示了一个高度多态的黄单胞菌 HrpG 毒力调控子。
BMC Genomics. 2024 Aug 9;25(1):777. doi: 10.1186/s12864-024-10684-6.
3
GamR, the LysR-Type Galactose Metabolism Regulator, Regulates hrp Gene Expression via Transcriptional Activation of Two Key hrp Regulators, HrpG and HrpX, in Xanthomonas oryzae pv. oryzae.GamR，一种LysR型半乳糖代谢调节因子，通过转录激活水稻白叶枯病菌中的两个关键hrp调节因子HrpG和HrpX来调控hrp基因的表达。
Appl Environ Microbiol. 2016 Jun 13;82(13):3947-3958. doi: 10.1128/AEM.00513-16. Print 2016 Jul 1.
4
Xanthomonas campestris VemR enhances the transcription of the T3SS key regulator HrpX via physical interaction with HrpG.野油菜黄单胞菌 VemR 通过与 HrpG 物理相互作用增强 T3SS 关键调控因子 HrpX 的转录。
Mol Plant Pathol. 2023 Mar;24(3):232-247. doi: 10.1111/mpp.13293. Epub 2023 Jan 10.
5
A novel regulatory role of HrpD6 in regulating hrp-hrc-hpa genes in Xanthomonas oryzae pv. oryzicola.在水稻黄单胞菌 pv.oryzicola 中，HrpD6 对 hrp-hrc-hpa 基因具有新的调控作用。
Mol Plant Microbe Interact. 2011 Sep;24(9):1086-101. doi: 10.1094/MPMI-09-10-0205.
6
Comparative genomics of a cannabis pathogen reveals insight into the evolution of pathogenicity in Xanthomonas.一种大麻病原体的比较基因组学揭示了对黄单胞菌致病性进化的见解。
Front Plant Sci. 2015 Jun 16;6:431. doi: 10.3389/fpls.2015.00431. eCollection 2015.
7
Involvement of and in the Virulence of Strain Aac5, Causal Agent of Bacterial Fruit Blotch in Cucurbits.与西瓜细菌性果斑病菌Aac5菌株毒力相关的[具体内容缺失]和[具体内容缺失]。
Front Microbiol. 2018 Mar 27;9:507. doi: 10.3389/fmicb.2018.00507. eCollection 2018.
8
[Expression of the hrcC, hrpE and hpa3 genes is not regulated by the hrpG and hrpX genes in a rice pathogen Xanthomonas oryzae pv. oryzicola].[水稻病原菌水稻黄单胞菌致病变种中hrcC、hrpE和hpa3基因的表达不受hrpG和hrpX基因调控]
Wei Sheng Wu Xue Bao. 2009 Aug;49(8):1018-25.
9
A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion System in Host.Lon 蛋白酶上的磷酸化开关调节宿主中的细菌 III 型分泌系统。
mBio. 2018 Jan 23;9(1):e02146-17. doi: 10.1128/mBio.02146-17.
10
HrcT is a key component of the type III secretion system in Xanthomonas spp. and also regulates the expression of the key hrp transcriptional activator HrpX.HrcT是黄单胞菌属中III型分泌系统的关键组成部分，并且还调节关键的hrp转录激活因子HrpX的表达。
Appl Environ Microbiol. 2014 Jul;80(13):3908-19. doi: 10.1128/AEM.00308-14. Epub 2014 Apr 18.

引用本文的文献

1
Extracellular Vesicles From Xylella fastidiosa Carry sRNAs and Genomic Islands, Suggesting Roles in Recipient Cells.来自桑萎蔫病菌的细胞外囊泡携带小RNA和基因组岛，表明其在受体细胞中发挥作用。
J Extracell Vesicles. 2025 Jun;14(6):e70102. doi: 10.1002/jev2.70102.
2
The pathogenicity-associated regulators participating in the regulatory cascade for RaxSTAB and RaxX in Xanthomonas oryzae pv. oryzae.参与调控稻黄单胞菌 RaxSTAB 和 RaxX 的调控级联的致病性相关调控因子。
Mol Plant Pathol. 2024 Nov;25(11):e70025. doi: 10.1111/mpp.70025.
3
Comparative transcriptomics reveals a highly polymorphic Xanthomonas HrpG virulence regulon.

本文引用的文献

1
Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA.RNA 结合蛋白 CsrA 进行全局调控的多种机制与途径
Front Microbiol. 2020 Oct 27;11:601352. doi: 10.3389/fmicb.2020.601352. eCollection 2020.
2
The stringent response and physiological roles of (pp)pGpp in bacteria.(pp)pGpp 在细菌中的严格响应和生理作用。
Nat Rev Microbiol. 2021 Apr;19(4):256-271. doi: 10.1038/s41579-020-00470-y. Epub 2020 Nov 4.
3
Genome-wide screen and functional analysis in Xanthomonas reveal a large number of mRNA-derived sRNAs, including the novel RsmA-sequester RsmU.
比较转录组学揭示了一个高度多态的黄单胞菌 HrpG 毒力调控子。
BMC Genomics. 2024 Aug 9;25(1):777. doi: 10.1186/s12864-024-10684-6.
4
The Transcriptional Regulator TfmR Directly Regulates Two Pathogenic Pathways in pv. .转录调节因子 TfmR 直接调控 pv. 中的两条致病途径。
Int J Mol Sci. 2024 May 28;25(11):5887. doi: 10.3390/ijms25115887.
5
Bacterial host adaptation through sequence and structural variations of a single type III effector gene.通过单一III型效应蛋白基因的序列和结构变异实现细菌宿主适应性。
iScience. 2024 Feb 15;27(3):109224. doi: 10.1016/j.isci.2024.109224. eCollection 2024 Mar 15.
6
Gene expression changes throughout the life cycle allow a bacterial plant pathogen to persist in diverse environmental habitats.在整个生命周期中，基因表达的变化使一种细菌植物病原体能够在不同的环境生境中持续存在。
PLoS Pathog. 2023 Dec 19;19(12):e1011888. doi: 10.1371/journal.ppat.1011888. eCollection 2023 Dec.
7
Seaweed as a Natural Source against Phytopathogenic Bacteria.海藻作为天然源对抗植物病原菌。
Mar Drugs. 2022 Dec 28;21(1):23. doi: 10.3390/md21010023.
8
Two Non-Necrotic Disease Resistance Types Distinctly Affect the Expression of Key Pathogenic Determinants of in Pepper.两种非坏死性抗病类型对辣椒中关键致病决定因素的表达有明显影响。
Plants (Basel). 2022 Dec 24;12(1):89. doi: 10.3390/plants12010089.
9
A putative multi-sensor hybrid histidine kinase, BarA , inhibits the expression of the type III secretion system regulator HrpG in .一种假定的多传感器杂合组氨酸激酶BarA，可抑制III型分泌系统调节因子HrpG在……中的表达。
Front Microbiol. 2022 Nov 30;13:1064577. doi: 10.3389/fmicb.2022.1064577. eCollection 2022.
10
Comparative transcriptomics reveal different genetic adaptations of biofilm formation in isolate 1JN2 in response to Cd treatment.比较转录组学揭示了分离株1JN2中生物膜形成对镉处理的不同遗传适应性。
Front Microbiol. 2022 Oct 4;13:1002482. doi: 10.3389/fmicb.2022.1002482. eCollection 2022.
在黄单胞菌中进行全基因组筛选和功能分析，揭示了大量的 mRNA 衍生的小 RNA，包括新型 RsmA 结合物 RsmU。
Mol Plant Pathol. 2020 Dec;21(12):1573-1590. doi: 10.1111/mpp.12997. Epub 2020 Sep 23.
4
Bactericidal type IV secretion system homeostasis in Xanthomonas citri.柑橘黄单胞菌杀菌型 IV 型分泌系统的动态平衡。
PLoS Pathog. 2020 May 26;16(5):e1008561. doi: 10.1371/journal.ppat.1008561. eCollection 2020 May.
5
Xanthomonas diversity, virulence and plant-pathogen interactions.黄单胞菌多样性、毒力及其与植物病原体的相互作用。
Nat Rev Microbiol. 2020 Aug;18(8):415-427. doi: 10.1038/s41579-020-0361-8. Epub 2020 Apr 28.
6
Analysis of HrpG regulons and HrpG-interacting proteins by ChIP-seq and affinity proteomics in Xanthomonas campestris.利用 ChIP-seq 和亲和蛋白质组学分析丁香假单胞菌中的 HrpG 调控组和 HrpG 互作蛋白。
Mol Plant Pathol. 2020 Mar;21(3):388-400. doi: 10.1111/mpp.12903. Epub 2020 Jan 8.
7
Stringent response regulators (p)ppGpp and DksA positively regulate virulence and host adaptation of Xanthomonas citri.严格响应调节因子（p）ppGpp 和 DksA 正向调控柑橘溃疡病菌的毒力和宿主适应性。
Mol Plant Pathol. 2019 Nov;20(11):1550-1565. doi: 10.1111/mpp.12865. Epub 2019 Oct 17.
8
Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas.植物病原菌黄单胞菌的宿主适应性、毒力和流行病学的机制研究进展。
FEMS Microbiol Rev. 2020 Jan 1;44(1):1-32. doi: 10.1093/femsre/fuz024.
9
A Decade Decoded: Spies and Hackers in the History of TAL Effectors Research.十年解码：TAL 效应物研究史中的间谍和黑客。
Annu Rev Phytopathol. 2019 Aug 25;57:459-481. doi: 10.1146/annurev-phyto-082718-100026. Epub 2019 Aug 6.
10
The type III secretion system needle, tip, and translocon.III 型分泌系统的针、尖端和转位器。
Protein Sci. 2019 Sep;28(9):1582-1593. doi: 10.1002/pro.3682. Epub 2019 Aug 2.