Hobbiss J H, Carr N D, Schofield P F
University Hospital of South Manchester.
J R Soc Med. 1988 Feb;81(2):95-6. doi: 10.1177/014107688808100215.
In a series of 20 patients undergoing elective colorectal surgery, 10 received an infusion of metronidazole 500 mg and 10 an infusion of 1500 mg commencing at the induction of anaesthesia. The concentrations of metronidazole in the plasma, rectus muscle and colon of the two groups during the course of the operation were compared. In those patients who received 1500 mg, the plasma and tissue concentrations were all well above the minimum inhibitory concentration (MIC) of metronidazole against Bacteroides fragilis. In those patients who received 500 mg, serum and tissue concentrations were at or only just above the MIC. It may be that 1500 mg would be a more effective dose of metronidazole for prophylactic use in colorectal surgery.
在一组20例行择期结直肠手术的患者中，10例在麻醉诱导时输注500毫克甲硝唑，10例输注1500毫克甲硝唑。比较了两组患者在手术过程中血浆、腹直肌和结肠中甲硝唑的浓度。在接受1500毫克甲硝唑的患者中，血浆和组织浓度均远高于甲硝唑对脆弱拟杆菌的最低抑菌浓度（MIC）。在接受500毫克甲硝唑的患者中，血清和组织浓度处于或仅略高于MIC。在结直肠手术预防性使用中，1500毫克甲硝唑可能是更有效的剂量。
