Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
J Clin Microbiol. 2021 May 19;59(6). doi: 10.1128/JCM.02146-20.
The threat posed by novel pandemics in the future remains active. Equipping our routine laboratory with clinical metagenomics to detect unknown threats early on offers a considerable advantage and may be feasible and scalable with the ability to identify complicated infectious diseases in routine care. Though several technical and regulatory challenges still exist, clinical metagenomics may improve individual patient outcomes and provide earlier warning signs to improve pandemic preparedness.
未来新型大流行病构成的威胁依然存在。在常规实验室中配备临床宏基因组学以尽早发现未知威胁具有相当大的优势，并且随着识别常规护理中复杂传染病能力的提高，这也许是可行和可扩展的。尽管仍存在一些技术和监管方面的挑战，但临床宏基因组学可能会改善个体患者的预后，并提供更早的预警信号，以提高大流行病防范能力。
